Hyperopia Treatment Study 1 (HTS1) - Glasses vs Observation

Inclusion Criteria

• Age 12 to 32 weeks
• Investigator is willing to prescribe glasses per protocol or observe the hyperopia untreated for 3 years unless specific criteria for deterioration outlined in section 3.3.3 are confirmed.
• Parent understands the protocol and is willing to accept randomization to either glasses or no glasses initially, and is willing to wear glasses as prescribed or accept that glasses will not be prescribed by the investigator unless specific deterioration criteria outlined in section 3.3.3 are confirmed.
• Parent has phone (or access to phone) and is willing to be contacted by Jaeb Center staff.
• Relocation outside of area of an active PEDIG site for this study within the next 36 months is not anticipated.

Exclusion Criteria

A patient is excluded for any of the following reasons:

• Any measurable heterotropia at distance (3 meters) or at near (1/3 meter) by cover/uncover testing. Note that patients with heterophoria are eligible.
• Previous documented strabismus (parental report must be confirmed by investigator)
• Manifest or latent nystagmus evident clinically
• Previous treatment of refractive error with glasses or contacts unless duration of glasses or contacts wear was one week or less and occurred more than 2 months prior to enrollment.
• Previous intraocular, refractive, or extraocular muscle surgery
• Previous amblyopia treatment
• Previous vergence/accommodative therapy
• Parental concerns over learning or development
• Ocular co-morbidity that may reduce visual acuity
• Symptoms of blur or asthenopia
• Developmental delay diagnosed by pediatrician or Individualized Education Program (IEP)
• Known neurological anomalies (e.g. cerebral palsy, Down syndrome)
• Inability to perform visual acuity ATS-HOTV testing if ≥ 36 months of age