N/A
Completed N=63
Cellular Dynamics of Subcutaneous Fat Distribution in Obese Women
Source: ClinicalTrials.gov NCT01748994 ↗Enrolled (actual)
63
Serious AEs
0.0%
Results posted
Apr 2021
Primary outcomePrimary: In Vivo Adipose Cell Formation (Adipogenesis) — -0.3; 1.8; -1.2; 2.1 percent
Summary
The body shape of obese women varies between having the majority of fat either above the waist ("apple" shape) or below the waist ("pear" shape). The study will investigate what restricts: apple"-shaped women from being "pear"-shaped at the cellular level. Since "pear" shaped women tend to have better health, this study will open the door to future research in regulating body shape and thus improving health.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY In Vivo Adipose Cell Formation (Adipogenesis) |
-0.3; 1.8; -1.2; 2.1 | — |
| SECONDARY Visceral Adipose Tissue (Percentage of Total Abdominal Adipose Tissue) |
0.5; -0.8 | — |
| SECONDARY Lipid Accretion in the Liver (Intra-hepatic Lipid; IHL) |
-0.7; -2.0 | — |
| SECONDARY Matsuda Index (Measure of Insulin Sensitivity) |
-0.39; 0.80 | — |
Eligibility Criteria
Inclusion Criteria
- You are a pre-menopausal woman between 18-40 years of age
- Your Body Mass Index (BMI, weight-to-height2 ratio) is 27 - 38 kg/m2, inclusive
- The ratio of your waist-to-hip circumferences is either >0.84 ("apple"-type body shape) or 140/90 at your screening visit
- Have you had a positive test for human immunodeficiency virus (HIV), hepatitis B or hepatitis C?
- You require chronic use of medications including diuretics, steroids, thyroid hormones, and adrenergic-stimulating agents (bronchodilators, nasal decongestants)
Data sourced from ClinicalTrials.gov (NCT01748994). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.