N/A N=33 Randomized Basic Science

Effects of Exercise Intervention on Aging-related Motor Decline

Aging · Exercise

Bottom Line

View on ClinicalTrials.gov: NCT01787292 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Feb 2020

Primary outcome: Primary: Estimate Cardiovascular Efficiency After Aerobic Exercise — 24.01; 31.2; 32.3 ml/kg(min) — p=.001

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Stretching Exercise Intervention (Behavioral); Aerobic Exercise Intervention (Behavioral); Self Monitoring (Behavioral)
Age: Adult, Older Adult · 60+ yrs
Sex: All
Sponsor: VA Office of Research and Development
Primary completion: Jul 2018

Outcome Measures

Outcome	Result	p-value
PRIMARY Estimate Cardiovascular Efficiency After Aerobic Exercise	24.01; 31.2; 32.3	.001 sig
PRIMARY Estimate of Cardiovascular Efficiency After Balance Training	22.83; 24.72; 23.58	.8
PRIMARY Silent Period Duration After Exercise Cycling Program	22; 26.2; 27.5	.05
PRIMARY Silent Period Duration for Balance Group	23; 21.2; 26.2	.05
PRIMARY fMRI Interhemispheric Inhibition Improvement After Aerobic Exercise	1.5; .58; .58	.01 sig
PRIMARY fMRI Interhemispheric Inhibition Improvement After Balance Training	1.49; .62; .62	.01 sig
PRIMARY Comparison of Cardiovascular Efficiency for Aerobic Exercise First Group After Home-based Intervention	25.25; 21.2	.01 sig
PRIMARY Comparison of Cardiovascular Efficiency for Balance Exercise First Group After Home-based Intervention	25.5; 20.8	.5
PRIMARY Comparison of Silent Period Duration After Aerobic Exercise	20.58; 26.2; 27.5	.6
PRIMARY Comparison of Silent Period Duration After Balance Exercise	26.54; 21.6	.4
SECONDARY Target Heart Rate Zone for Balance First Participants	58.4; 88.5	.05
SECONDARY Target Heart Rate Zone After Aerobic Exercise First	93.7; 70.6	.25
SECONDARY Heart Rate Workload After Home Based Intervention	78; 48	.01 sig

Summary

The purpose of this research study is to test whether differing levels of physical fitness affects patterns of motor dexterity and brain activity that have been shown to differ due to aging. Testing will take place at the Atlanta VA Medical Center and at Emory University. Participants will be healthy adults within the target age range of 60-85 for the study. The study will require multiple visits over 15 months. There will be about 64 people volunteering for this study.

Eligibility Criteria

Inclusion Criteria

Living persons between 60 and 85 years of age

Exclusion Criteria

unmanaged diabetes
participants completing vigorous exercise per week
participants whose profession requires vigorous physical labor
contraindication to magnetic resonance imaging

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01787292). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.