Phase 2
Completed N=40
An Adaptive Treatment Strategy for Adolescent Depression
Source: ClinicalTrials.gov NCT01802437 ↗Enrolled (actual)
40
Serious AEs
10.0%
Results posted
Jul 2019
Primary outcomePrimary: CDRS-R Score — 34.94; 40.65 score on a scale
Summary
The purpose of the study is:
1. to find out how long teenagers getting talk therapy (interpersonal psychotherapy) for depression should get therapy before the therapist decides whether or not the teenager is improving enough, and
2. to compare two ways of providing treatment to teenagers who have not improved enough.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY CDRS-R Score |
34.94; 40.65 | — |
| PRIMARY CGAS Score |
66.52; 60.66 | — |
| PRIMARY SAS-SR Score |
2.16; 2.35 | — |
Eligibility Criteria
Inclusion Criteria
- Adolescent meets DSM-IV-TR criteria for a diagnosis of Major Depressive Disorder, Dysthymia, or Depressive Disorder NOS; demonstrate symptoms of depression (CDRS-R > 35); and demonstrate impairment in general functioning (CGAS 3 months) will be eligible to participate in the studies.
- Adolescent that have already received an adequate trial of IPT-A or fluoxetine.
- Female adolescents who are pregnant, breastfeeding, or having unprotected sexual intercourse.
Data sourced from ClinicalTrials.gov (NCT01802437). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.