Phase 2 N=51 Omega-3 Fatty Acids in Adolescent Depression
Adolescent Depression
Primary: Children's Depressive Rating Scale - Revised (CDRS-R) — 50.2; 49.5; 35.2; 36.5 units on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=48 Group Depression Treatment for Autistic Youth
Autism Spectrum Disorder · Depression · Suicidal Ideation
Primary: Change in Severity of Adolescent Depressive Symptoms, Self-report — 8.14 T-score
N/A N=15 Adolescent Attention to Emotion Study
Depression
Primary: Affect-biased Attention Following Neurofeedback (Immediately Post-Intervention) — .41 Proportion (0-1) — p=.004
N/A N=39 Transcranial Magnetic Stimulation for Adolescent Depression
Major Depressive Disorder
Primary: Hamilton Depression Rating Scale — 9.38 score on a scale
Phase 2 N=90 An Adaptive Algorithm-Based Approach to Treatment for Adolescent Depression
Depressive Disorder
Primary: Children's Depression Rating Scale - Revised — 36.0; 37.5 score on a scale — p=0.76
N/A N=223 Self-guided Treatment for Adolescents Navigating Depression
Depressive Symptoms · Depression · Depressive Disorder
Primary: Depressive Symptom Severity at Post-intervention — 8.39; 11.03 units on a scale — p=<0.001
N/A N=16 Testing TRUST Depression Management Intervention
Depressive Symptoms · Quality of Life
Primary: Patient Health Questionnaire-8 Adolescent — 6.17; 9.43; 6.80; 8.29 units on a scale
N/A N=32 Activating and Connecting Teens (ACT) Study
Depression
Primary: Depression — 9.63 score on a scale
N/A N=2,452 Testing Scalable, Single-Session Interventions for Adolescent Depression in the Context of COVID-19
Depression
Primary: Change in Adolescent Depressive Symptom Severity — 14.31; 14.15; 14.22; 12.57 Score on a scale
N/A N=15 The S.M.A.R.T. Project: Stress Management and Resilience Training for Teens
Depression Mild · Resilience, Psychological · Adolescent Behavior
Primary: Time to Incident Depression — 36; 18.86 weeks — p=0.02
Phase 1 N=497 Middle School to High School Transition Project: Depression and Substance Abuse Prevention
Depression · Substance-Related Disorders
Primary: Change in Short Moods and Feelings Questionnaire (SMFQ) — 2.19; 1.21 units on a scale — p=<0.05
N/A N=60 A CBT-based Mobile Intervention as First Line Treatment for Adolescent Depression During COVID-19
Depression
Primary: Phase I - Feasibility (Eligibility) — 35; 25 Participants
N/A N=24 Concurrent Treatment for Depressed Parents and DepressedAdolescents
Depression · Suicide
Primary: Beck Depression Inventory - Adolescent Report, Change in Symptom Level — -17.5; -14.1 change in BDI (-60 to 60 possible range) — p=.46
Phase 2 N=40 An Adaptive Treatment Strategy for Adolescent Depression
Adolescent Depression
Primary: CDRS-R Score — 34.94; 40.65 score on a scale
N/A N=80 Examining Reward-Related Predictors and Mechanisms of Change in BA Treatment for Anhedonic Adolescents
Anhedonia
Primary: Change in Anhedonic (Snaith-Hamilton Pleasure Scale; SHAPS) Symptoms — 7.06; -1.29 units on SHAPS scale
Phase 2 N=16 The Role Of Omega-3 Fatty Acids In Adolescent Depression
Depressive Disorder, Major
Primary: ACC Glx/Water — 19.21; 18.99; 19.28; 20.61 ratio * 10^-4
N/A N=112 Safety and Effectiveness of NeuroStar® Transcranial Magnetic Stimulation (TMS) Therapy in Depressed Adolescents
Major Depressive Disorder
Primary: Hamilton Depression Rating Scale-24(HAMD24) Total Score Change From Baseline Value. — -11.1; -10.6 score on a scale
N/A N=12,909 Universal vs. Targeted School Screening for Adolescent Major Depressive Disorder
Major Depressive Disorder · Major Depressive Episode
Primary: Major Depressive Disorder (MDD) Composite: Positive Patient Health Questionnaire-9 (PHQ-9; Universal Arm) or MDD Concern Prompting Student Assistance Program (SAP)…
N/A N=95 Adolescent Depression Screening and Treatment in Mozambican Primary Care
Depression · Adolescent Behavior
Primary: Change in PHQ-A Score From Baseline to 6 Months Post-intervention — -35.9; -54.0 percent change
N/A N=30 Treatments for Improving Mood in Depressed Teens-3
Depression
Primary: Acceptability — 11; 13 Participants
N/A N=5 iTBS for Adolescent Depression: An Open Label Study Evaluating Safety and Efficacy of Treatment
Depression
Primary: Change in HAM-D Score From Baseline to Week 1 — -7.6 score on a scale
Phase 2 N=14 Ketamine in Adolescents With Treatment-Resistant Depression
Major Depressive Disorder
Primary: Number of Responders Measured by Clinical Global Impression (CGI) — 5 Participants
N/A N=63 E-Mental Health Adolescent Depression Program (LEAP)
Depression
Primary: Children's Depression Rating Scale Revised (CDRS-R) — 57.18; 61.67; 44.94; 58.93 units on a scale
Phase 2 N=15 An Adaptive Treatment Strategy for Adolescent Depression-Continuation
Adolescent Depression
Primary: Children's Depression Rating Scale-Revised (CDRS-R) — 32.38; 26.67; 51; 45 score on a scale
N/A N=8 An Evaluation of Safety and Feasibility Using Repetitive Transcranial Magnetic Stimulation (rTMS) in Adolescents With Depression
Depression
Primary: Change in Cognitive Status as Measured by the Children's Auditory Verbal Learning Test 2 (CAVLT-2) — -11.3 units on a scale
N/A N=45 CBT Enhanced With Social Cognitive Training
Depression
Primary: Faux Pas Recognition Test — 0.901; 0.854 score on a scale — p=< 0.05
N/A N=11 Treatments for Improving Mood in Depressed Teens-2
Depression
Primary: Acceptability — 9 Participants
Phase 2 N=70 Effectiveness of Fluoxetine in Young People for the Treatment of Major Depression and Marijuana Dependence
Depressive Disorder, Major · Cannabis Abuse
Primary: Days Per Week of Cannabis Use. — 3.88; 3.1 Days of cannabis use per week — p=<0.05
N/A N=29 Engaging Black Youth in Depression and Suicide Prevention Treatment Within Urban Schools
Depression · Suicidal Ideation
Primary: Center for Epidemiological Studies-Depression Scale — 36.84; 40.90 units on a scale
N/A N=120 Mindfulness-Based Intervention for Depression and Insulin Resistance in Adolescents
Type 2 Diabetes · Depression · Insulin Resistance
Primary: Intervention Fidelity — 90; 90; 97.5; 100 Expert ratings ranging from 0-100%