Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies

Inclusion Criteria

• INCLUSION CRITERIA PRIOR TO TRANSPLANT:
• The clinical trial will be offered to all high risk (defined 3 below) patients with hematologic malignancies who require stem cell transplants as part of their standard of care using matched related or unrelated donors
• Patients with high risk myeloid or lymphoid malignancies at stem cell transplant following American Society for Blood and Marrow Transplantation (ASBMT) criteria, including but not limited to conditions listed; these criteria apply BEFORE cyto-reductive therapy given within 28 days of planned conditioning:
• Refractory acute myelogenous or lymphoid leukemia
• Relapsed acute myelogenous or lymphoid leukemia
• Myelodysplastic syndromes with 5% or more blasts
• Chronic myelogenous leukemia in chronic phase 3 or more, blast phase presently, or second accelerated phase
• Recurrent or refractory malignant lymphoma or Hodgkin's disease with less than a partial response at transplant
• High risk chronic lymphocytic leukemia defined as no response or stable disease to the most recent treatment regimen
• DONORS: Matched related or unrelated donor stem cell transplant (SCT) matched at human leukocyte antigen (HLA) A- B, C, and DRB1 by molecular methods; 7 of 8 matched donor acceptable for related donors
• T-cell depletion with anti-thymocyte globulin (ATG) (rabbit or horse) or at least 30 mg of alemtuzumab total in the conditioning regimen
• Immune suppression; planned post-transplant immune suppression should include tacrolimus or cyclosporin monotherapy (i.e., calcineurin inhibitor or CN) for alemtuzumab regimens and a second immune suppressant for ATG treated patients; other agents may be used if CN intolerance or toxicity occurs post-transplant
• Zubrod performance status (PS) 0-2 or equivalent Karnofsky PS
• Eligible for allogeneic transplant in the treating physicians' judgment and by institutional standards
• ELIGIBILITY TO RECEIVE DLI POST-TRANSPLANT:
• Donor lymphocytes available or able to be collected
• No evidence of disease by standard morphology; minimal residual disease or molecular evidence of disease will not exclude
• Absolute neutrophil count >= 500/μl
• Platelet count >= 20, 000/μl without transfusion for 7 days
• Serum glutamic oxaloacetic transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT) = = 2.0 mg/dL
• SGOT and SGPT >= 5 x ULN; liver biopsy preferred for such patients
• Bilirubin >= 3 x ULN (unless Gilbert's syndrome)
• Diffusing capacity of the lung for carbon monoxide (DLCO) < 50% corrected for hemoglobin
• Left ventricular ejection fraction or shortening fraction < 40%
• Unlikely to be able to procure additional donor lymphocytes