Phase 4
Completed N=204
IV Acetaminophen for Postoperative Pain After Pelvic Organ Prolapse Repair
Source: ClinicalTrials.gov NCT02155738 ↗Enrolled (actual)
204
Serious AEs
2.5%
Results posted
Nov 2018
Primary outcomePrimary: Change From Baseline in Postoperative Pain — 20.5; 29.2; 20.7; 20.1 units on a scale — p=<0.05
◆ Published Evidence
Emerging
19citations · ~3 / year
Intravenous Acetaminophen Before Pelvic Organ Prolapse Repair: A Randomized Controlled Trial.
Summary
The purpose of this study is to determine whether preoperative IV Acetaminophen reduces postoperative pain and narcotic consumption in women undergoing surgical repair of pelvic organ prolapse.
Linked Publications
-
Intravenous Acetaminophen Before Pelvic Organ Prolapse Repair: A Randomized Controlled Trial.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change From Baseline in Postoperative Pain |
20.5; 29.2; 20.7; 20.1 | <0.05 sig |
| PRIMARY Cumulative Narcotic Consumption Over the First 24 Hours |
32.5; 31.6; 47.4; 44.5 | <0.05 sig |
| SECONDARY Interference of Pain With Physical, Mental and Social Activities |
18.4; 22.0; 22.9; 25.2 | — |
Eligibility Criteria
Inclusion Criteria
- Women ≥ 18 years of age
- scheduled to undergo surgery for POP via a vaginal or minimally invasive (laparoscopic/robotic) route at the University of Pittsburgh Medical Center
- women anticipated to have a hospital stay ≥24 hours
Exclusion Criteria
- allergy/intolerance to acetaminophen
- hepatic dysfunction
- significant alcohol use - defined as patient reported consumption of more than 7 standard drinks per week and/or 3 drinks per day
Data sourced from ClinicalTrials.gov (NCT02155738) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.