Phase 3
Completed N=643
"A Long-Term Safety Study of JZP-110 in the Treatment of Excessive Sleepiness in Subjects With Narcolepsy or OSA"
Source: ClinicalTrials.gov NCT02348632 ↗Enrolled (actual)
643
Serious AEs
3.4%
Results posted
Jun 2019
Primary outcomePrimary: Change in Epworth Sleepiness Scale (ESS) Score — 1.6; 5.3 points on a scale
◆ Published Evidence
Highly cited
249citations · ~42 / year
Long-term study of the safety and maintenance of efficacy of solriamfetol (JZP-110) in the treatment of excessive sleepiness in participants with narcolepsy or obstructive sleep apnea.
Summary
This is a Phase 3 study to assess the long-term safety and maintenance of efficacy of JZP-110 in subjects who have completed Study 14-002, 14-003, 14-004, 15-004, 15-005, ADX-N05 201, or ADX-N05 202.
Linked Publications (4)
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Long-term study of the safety and maintenance of efficacy of solriamfetol (JZP-110) in the treatment of excessive sleepiness in participants with narcolepsy or obstructive sleep apnea.
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Long-term effects of solriamfetol on quality of life and work productivity in participants with excessive daytime sleepiness associated with narcolepsy or obstructive sleep apnea.
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Effects of solriamfetol in a long-term trial of participants with obstructive sleep apnea who are adherent or nonadherent to airway therapy.
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Effects of solriamfetol treatment on body weight in participants with obstructive sleep apnea or narcolepsy.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Epworth Sleepiness Scale (ESS) Score |
1.6; 5.3 | — |
| SECONDARY Subjects Reported as Worse on the Patient Global Impression of Change (PGIc) |
28.2; 64.5 | — |
| SECONDARY Subjects Reported as Worse on the Clinical Global Impression of Change (CGIc) |
28.7; 63.8 | — |
Eligibility Criteria
Major Inclusion Criteria:
- Subject meets one of the following:
- Completed Study 14-002 or 14-003 (Group A)
- Completed Study 14-004, 15-004, 15-005, ADX-N05 201 or ADX-N05 202 (Group B)
- Body mass index from 18 to <45 kg/m2
- Consent to use a medically acceptable method of contraception
- Willing and able to provide written informed consent
Major Exclusion Criteria:
- Female subjects who are pregnant, nursing, or lactating
- Any other clinically relevant medical, behavioral, or psychiatric disorder other than narcolepsy or OSA that is associated with excessive sleepiness
- History or presence of bipolar disorder, bipolar related disorders, schizophrenia, schizophrenia spectrum disorders, or other psychotic disorders according to DSM-5 criteria
- Presence of any acutely unstable medical condition, behavioral or psychiatric disorder (including active suicidal ideation), or surgical history that could affect the safety of the subject or interfere with study efficacy or safety assessments, or the ability of the subject to complete the trial per the judgment of the Investigator
- History of bariatric surgery within the past year or a history of roux-en-y procedure
- Presence or history of significant cardiovascular disease
- Use of any over the counter (OTC) or prescription medications that could affect the evaluation of excessive sleepiness
- Received an investigational drug other than JZP-110 in the past 30 days or five half-lives (whichever is longer)
- History of phenylketonuria (PKU) or history of hypersensitivity to phenylalanine-derived products
Data sourced from ClinicalTrials.gov (NCT02348632) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.