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Home › Conditions › Narcolepsy

Narcolepsy

Part of Sleep Disorders, Intrinsic

Subtypes of Narcolepsy

Narcolepsy Type 1 2

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Narcolepsy

24 trials tracked for Narcolepsy: 11 in phase 3 or 4 and 5 with published results. The most-cited published study has 249 citations.

24Trials tracked
11Phase 3 & 4
0Recruiting
5With published results
Phase distribution
Phase 4 2 Phase 3 9 Phase 2 8 Phase 1 1 Other / NA 4
  1. Phase 3 "A Long-Term Safety Study of JZP-110 in the Treatment of Excessive Sleepiness in Subjects With Narcolepsy or OSA" Completed · 249 cited
  2. Phase 3 "Twelve-week Study of the Safety and Efficacy of JZP-110 in the Treatment of Excessive Sleepiness in Narcolepsy" Completed · 192 cited
  3. Phase 4 A Switch Study From High-Sodium Oxybate to Xywav to Evaluate Changes in Blood Pressure in Participants With Narcolepsy Completed · 3 cited
  4. Phase 3 Once-Nightly Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsy Completed · 3 cited
  5. Phase 4 An Interventional Safety Switch Study (Segue Study) of XYWAV in Narcolepsy Completed · 2 cited
  6. Phase 3 Trial of Xyrem® (Sodium Oxybate) for the Treatment of Narcolepsy Completed
Show 18 more trials
  1. Phase 3 Extension Study of the Safety and Efficacy of Armodafinil in the Treatment of Patients With Excessive Sleepiness Completed
  2. Phase 3 Armodafinil (CEP-10953) for Treatment of Narcolepsy, Obstructive Sleep Apnea/Hypopnea Syndrome, or Chronic Shift Work Sleep Disorder Completed
  3. Phase 3 Safety and Efficacy Study of Armodafinil (CEP-10953) in the Treatment of Excessive Sleepiness Associated With Narcolepsy Completed
  4. Phase 3 Trial Comparing Effects of Xyrem Taken Orally and Modafinil With Placebo in Treating Daytime Sleepiness in Narcolepsy Completed
  5. Phase 3 Study to Assess Patient Reported Outcomes With Armodafinil Treatment for Excessive Sleepiness in Adults With Narcolepsy or Obstructive Sleep Apnea/Hypopnea Syndrome Completed
  6. Phase 2 Clarithromycin for the Treatment of Hypersomnia Completed
  7. Phase 2 Safety and Efficacy of THN102 on Sleepiness in Narcoleptic Patients Completed
  8. Phase 2 Clinical Outcomes in Narcolepsy and Cataplexy: An Evaluation of Reboxetine Treatment (CONCERT) Completed
  9. Phase 2 A Study to Evaluate Safety, and Efficacy of SUVN-G3031 (Samelisant) in Patients With Narcolepsy With and Without Cataplexy Completed
  10. Phase 2 A Study of the Safety and Effectiveness of ADX-N05 in the Treatment of Excessive Daytime Sleepiness Completed
  11. Phase 2 A Study Of A Novel Compound For Excessive Daytime Sleepiness Associated With Narcolepsy Completed
  12. Phase 2 Study Assessing Effects of JZP-110 on Driving Performance in the Treatment of Excessive Sleepiness in Narcolepsy Completed
  13. Phase 2 A Study of the Safety and Effectiveness of ADX-N05 for Excessive Daytime Sleepiness in Subjects With Narcolepsy Completed
  14. Phase 1 A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of TAK-925 in Healthy Volunteers and Participants With Narcolepsy Completed
  15. N/A Risk of Narcolepsy Associated With Administration of H1N1 Vaccine Completed
  16. N/A Advancing Understanding of Transportation Options Completed
  17. N/A A Study to Collect Information of People With Narcolepsy in Spain Completed
  18. N/A Awareness and Self-Compassion Enhancing Narcolepsy Treatment Completed

Showing the 24 most-cited and recently-updated of 24 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Observational study finds autonomic dysfunction in idiopathic hypersomnia versus narcolepsy and controls
Neurology
Observational study finds autonomic dysfunction in idiopathic hypersomnia versus narcolepsy and controls Do you feel exhausted all day? New data shows your heart may struggle when you stand up
This observational study assessed autonomic nervous system function in adults with idiopathic hypersomnia (IH), type 1 narcolepsy (NT1), and…
People with idiopathic hypersomnia have hearts that race faster when standing and struggle to sweat properly, revealing hidden autonomic ner…
medRxiv Apr 16, 2026
Narrative review synthesizes evidence on narcolepsy type 1, proposes integrative clinical algorithm
Psychiatry Sys. Review
Narrative review synthesizes evidence on narcolepsy type 1, proposes integrative clinical algorithm Could narcolepsy be an immune disorder? A new review suggests a shift in thinking
A narrative review synthesizes existing literature on narcolepsy type 1, proposing it aligns with immune-mediated neurological disease spect…
Narcolepsy may be an immune disorder, not just a sleep issue, prompting a new model to treat patients based on their unique biology and symp…
Frontiers Apr 3, 2026
FDA Approves Methylphenidate Hydrochloride Extended-Release Tablets for ADHD and Narcolepsy
Psychiatry FDA Approval
FDA Approves Methylphenidate Hydrochloride Extended-Release Tablets for ADHD and Narcolepsy The FDA has approved a new, longer-acting generic version of a common ADHD and narcolepsy medication
The FDA has approved methylphenidate hydrochloride extended-release tablets for the treatment of Attention Deficit Hyperactivity Disorder (A…
The FDA approved a new generic ADHD and narcolepsy medicine that works for about 8 hours, offering a longer-lasting option for patients 6 ye…
FDA Mar 31, 2026