Phase 2
Completed N=807
Web-based Interpretation Training For Anxiety
Source: ClinicalTrials.gov NCT02382003 ↗Enrolled (actual)
807
Serious AEs
0.0%
Results posted
Feb 2025
Primary outcomePrimary: Change in Recognition Ratings (Positive Interpretation Bias) — 1.23; 1.19; 1.22; 1.16 score on a scale — p=0.005
Summary
The study aims to develop a web-based Cognitive Bias Modification infrastructure to train interpretations, and evaluate the usability, acceptability, and feasibility of the program to reduce anxiety symptoms.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Recognition Ratings (Positive Interpretation Bias) |
1.23; 1.19; 1.22; 1.16; 1.17; 1.22 | 0.005 sig |
| PRIMARY Change in Overall Anxiety Severity and Impairment Scale |
10.367925; 11.066667; 11.470085; 10.544118; 11.131783; 10.486111 | 0.003 sig |
| PRIMARY Change in Recognition Ratings (Negative Interpretation Bias) |
1.66; 1.70; 1.75; 1.74; 1.77; 1.77 | <0.001 sig |
| PRIMARY Change in Brief Bodily Sensations Interpretations Questionnaire |
1.81; 1.83; 1.93; 1.91; 1.90; 1.85 | < 0.001 sig |
| SECONDARY Multi-Session User Experience Questionnaire |
2.54; 2.31; 2.66; 2.74; 2.81; 2.21 | — |
| SECONDARY Impact of Anxious Imagery Prime (Change Over Time is Exploratory But Should Show Anxious/Neutral Prime Differences; e.g., in Subjective Distress) |
18.73311; 7.899425; 18.77632; 7.927326; 18.57796; 8.783981 | — |
| SECONDARY Change in Depression, Anxiety, Stress Scales-Short Form: Anxiety Subscale |
22.4; 22.64; 24.7; 22.7; 23.84; 22.48 | — |
| SECONDARY Change in Quality of Life Scale |
3.196459; 3.106346; 3.081101; 3.169298; 3.157229; 3.283237 | — |
Eligibility Criteria
Inclusion Criteria
The target population will be adults age 18 and over who score in the moderate to extremely severe anxiety range (i.e., 10 or higher) on the Depression, Anxiety, Stress Scales - Short Form: Anxiety Subscale and have regular access to the Internet.
Exclusion Criteria
None listed.
Data sourced from ClinicalTrials.gov (NCT02382003). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.