N/A N=42 Randomized Double-blind Treatment

A Novel Neurorehabilitation Approach for Cognitive Aging With HIV

HIV · Aging

Bottom Line

View on ClinicalTrials.gov: NCT02391311 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

May 2017

Primary outcome: Primary: Change in the Processing of Speed — 2.63; 6.06 units on a scale

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: transcranial direct current stimulation (tDCS) (Device)
Age: Adult, Older Adult · 50+ yrs
Sex: All
Sponsor: University of Alabama at Birmingham
Primary completion: Jan 2016

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in the Processing of Speed	2.63; 6.06	—
SECONDARY Change in Driving Simulator Performance	1.867; -1.800	—

Summary

The goal of this study is to conduct a small, self-contained project to test the hypothesis that tDCS will augment SOP cognitive remediation therapy (CRT) in older HIV+ adults. The investigators will randomly assign 60 HIV+ older adults (i.e., ≥ 50 years old) to 10-hours in either a SOP CRT + sham tDCS condition (n=30) or SOP CRT + active tDCS condition (n=30) and examine neurocognitive functioning at baseline and 6 weeks post-intervention. Hypothesis 1: The SOP CRT + active tDCS condition will show larger proximal (i.e., SOP) gains than the SOP CRT + sham tDCS condition. Hypothesis 2: The active tDCS condition will demonstrate generalization to secondary neurocognitive domains compared to the sham tDCS condition.

Eligibility Criteria

Inclusion Criteria

HIV+
Aged 50 and older
Patient at University HIV/AIDS Clinic

Exclusion Criteria

Not homeless
Not blind or deaf
No significant neuromedical issues (e.g., schizophrenia, bipolar disorder, stroke, epilepsy or history of seizures)
No pacemaker or other biomedical devices or metal implants
No untreated hypertension
Not undergoing chemo or radiation
No head injury with LOC greater than 30 mins

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02391311). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.