Phase 2
Completed N=11
Transdermal Estrogen in Older Premenopausal Women With Anorexia Nervosa
Source: ClinicalTrials.gov NCT02475265 ↗Enrolled (actual)
11
Serious AEs
0.0%
Results posted
Jul 2019
Primary outcomePrimary: Percent Change in Bone Mineral Density (BMD) of Lumbar Spine by Dual Energy X-ray Absorptiometry (DXA) — 2.0 percent change
Summary
Decreased bone strength is a common and serious medical problem present in many women with anorexia nervosa. Women with decreased bone strength are more likely to suffer broken bones than women with normal bone strength.
This study will investigate whether the use of transdermal estrogen can improve bone mineral density (BMD) and bone microarchitecture in women with anorexia nervosa anorexia nervosa when used for 6 months.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Percent Change in Bone Mineral Density (BMD) of Lumbar Spine by Dual Energy X-ray Absorptiometry (DXA) |
2.0 | — |
Eligibility Criteria
Inclusion Criteria
- Female; ages 25-50 years
- Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-V) psychiatric criteria for AN, including 3 times the upper limit of normal
- Fasting serum triglyceride level > 150 mg/dL
- Pregnant or breastfeeding
- Active substance abuse
Data sourced from ClinicalTrials.gov (NCT02475265). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.