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Home › Conditions › Anorexia nervosa

Anorexia nervosa

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Anorexia nervosa

31 trials tracked for Anorexia nervosa: 8 in phase 3 or 4 and 1 with published results. The most-cited published study has 393 citations.

31Trials tracked
8Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 2 Phase 3 6 Phase 2 7 Phase 1 1 Other / NA 15
  1. Phase 4 Fluoxetine to Prevent Relapse and Enhance Psychological Recovery in Women With Anorexia Nervosa Completed · 393 cited
  2. Phase 4 A Double-blind, Placebo Controlled Trial of Risperidone for the Treatment of Anorexia Nervosa Completed
  3. Phase 3 Effects of Anorexia Nervosa on Peak Bone Mass Completed
  4. Phase 3 Effects of Denosumab on Bone Mineral Density in Women With Anorexia Nervosa: A Pilot Study Completed
  5. Phase 3 Effects of Romosozumab on Bone Density in Women With Anorexia Nervosa Completed
  6. Phase 3 Effects of Anorexia Nervosa on Bone Mass in Adolescents Completed
Show 25 more trials
  1. Phase 3 Adrenal and Gonadal Hormone Replacement in Anorexia Nervosa Completed
  2. Phase 3 Bone Loss in Women With Anorexia Nervosa Completed
  3. Phase 2 Treatment of Anxiety and Anorexia Nervosa in Adolescents Completed
  4. Phase 2 The Role of Parathyroid Hormone (PTH) in Low Bone Mass in Anorexia Nervosa Completed
  5. Phase 2 Hormonal Factors in the Treatment of Anorexia Nervosa Completed
  6. Phase 2 Safety Profile of Insulin Like Growth Factor-1 (IGF-I) Administration in Adolescents Completed
  7. Phase 2 Olanzapine in the Treatment of Patients With Anorexia Nervosa Completed
  8. Phase 2 Effect of Growth Hormone on Bone Metabolism in Anorexia Nervosa Completed
  9. Phase 2 Transdermal Estrogen in Older Premenopausal Women With Anorexia Nervosa Completed
  10. Phase 1 Dopamine Receptor Contributions to Prediction Error and Reversal Learning in Anorexia Nervosa Completed
  11. N/A Study of Refeeding to Optimize iNpatient Gains Completed
  12. N/A Effect Of Biomechanical Stimulation On Skeletal Health In Adolescent And Young Women With Anorexia Nervosa Completed
  13. N/A Feasibility Study Comparing Standard FBT and Guided Self-Help FBT for Adolescent Anorexia Nervosa Completed
  14. N/A Shifting Perspectives: Enhancing Outcomes in Anorexia Nervosa With CRT Completed
  15. N/A Olanzapine Versus Placebo for Outpatients With Anorexia Nervosa Completed
  16. N/A IGF-1 and Bone Loss in Women With Anorexia Nervosa Completed
  17. N/A Optimizing Provider Training in Eating Disorders (OPTED) Completed
  18. N/A Evaluation of the Communities of Healing Mentorship/Support Group Program: Assessment of Preliminary Efficacy Completed
  19. N/A The Effectiveness and Mechanism Study of Auricular Needling in Treating Cancer Induced Anorexia Completed
  20. N/A Helping HAND: Healing Anorexia Nervosa Digitally Completed
  21. N/A PET Imaging Study of Recovered Anorexics Completed
  22. N/A The Role of Lactobacillus Reuteri in Children and Adolescents With Anorexia Nervosa Completed
  23. N/A Trial of Quetiapine in Anorexia Nervosa Completed
  24. N/A App-Based Mindfulness Training for Individuals With Anorexia Nervosa and Bulimia Nervosa Completed
  25. N/A Parent Emotion Coaching for Anorexia Nervosa Completed

Showing the 31 most-cited and recently-updated of 31 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Anorexia nervosa: what the trials found

Pharmacological interventions for anorexia nervosa have shown mixed results regarding physical and psychological outcomes. Fluoxetine was associated with a significant reduction in psychological symptoms as measured by the Beck Anxiety Inventory (p=0.007), though it did not result in a statistically significant change in weight per month (p=0.75) or patient retention at one year (p=0.57) 3. Risperidone showed no significant impact on reaching normal eating behaviors (p=0.55) or improving scores on the Color A Person Test (p=0.47) 4.

Evidence regarding bone health in this population is established through various hormonal and pharmacological agents. Testosterone significantly increased bone mineral density (p<0.0001) and improved markers of bone metabolism (p=0.002) 9. Physiologic estrogen/progesterone also resulted in a significant increase in spine bone density over 18 months (p<0.05) 10. Additionally, Romosozumab showed a significant positive change in lumbar spine bone mineral density at 12 months (p=<0.0001) 5, while Denosumab showed a statistically significant increase in lumbar spine bone mineral density (p=0.009) 6.

Recent results — preliminary, needs further review

  • A mobile app intervention was found to significantly improve eating disorder psychopathology as measured by the Eating Disorder Examination-Questionnaire (p=0.0003) and significantly impact Body Mass Index (p=0.0166), though it did not significantly change the number of reported eating behaviors (p=0.950) 1. Web-based training for family-based treatment did not show significant differences in completion rates, knowledge assessment scores, or the number of participants receiving consultation at 12 months 19.

For the clinician treating this condition

  • Fluoxetine is associated with a reduction in anxiety symptoms but does not significantly impact weight gain or retention in anorexia patients.
  • Hormonal therapies (Testosterone and Physiologic Estrogen/Progesterone) and specific agents like Romosozumab are effective for improving bone mineral density.

AI synthesis of 8 cited trials, updated Jun 26, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Evaluating the Association of Childhood Sexual Abuse and Adolescent Anorexia Nervosa
Pediatrics Meta-analysis
Evaluating the Association of Childhood Sexual Abuse and Adolescent Anorexia Nervosa Childhood sexual abuse linked to higher rates of anorexia nervosa
Evidence suggests a significant link between childhood sexual abuse and anorexia nervosa, particularly in patients exhibiting binge-eating b…
Research shows a strong link between childhood sexual abuse and anorexia nervosa in teens, especially those who binge or purge.
Frontiers Sep 3, 2026
Chinese female patients with anorexia nervosa showed no significant gut microbiota differences versus healthy controls
Psychiatry Cohort
Chinese female patients with anorexia nervosa showed no significant gut microbiota differences versus healthy controls The Gut-Brain Link in Anorexia Is Real — But More Complicated Than Expected
This cohort study compared gut microbiota profiles in 30 female patients with anorexia nervosa (AN) and 30 sex- and age-matched healthy cont…
Women with anorexia nervosa have different gut bacteria than healthy people, but these microbes don't predict illness severity or childhood …
Frontiers Apr 18, 2026