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Anorexia nervosa

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for Anorexia nervosa

31 trials tracked for Anorexia nervosa: 8 in phase 3 or 4 and 1 with published results. The most-cited published study has 392 citations.

31Trials tracked
8Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 2 Phase 3 6 Phase 2 7 Phase 1 1 Other / NA 15
  1. Phase 4 Fluoxetine to Prevent Relapse and Enhance Psychological Recovery in Women With Anorexia Nervosa Completed · 392 cited
  2. Phase 4 A Double-blind, Placebo Controlled Trial of Risperidone for the Treatment of Anorexia Nervosa Completed
  3. Phase 3 Effects of Anorexia Nervosa on Peak Bone Mass Completed
  4. Phase 3 Effects of Denosumab on Bone Mineral Density in Women With Anorexia Nervosa: A Pilot Study Completed
  5. Phase 3 Effects of Romosozumab on Bone Density in Women With Anorexia Nervosa Completed
  6. Phase 3 Effects of Anorexia Nervosa on Bone Mass in Adolescents Completed
Show 25 more trials
  1. Phase 3 Adrenal and Gonadal Hormone Replacement in Anorexia Nervosa Completed
  2. Phase 3 Bone Loss in Women With Anorexia Nervosa Completed
  3. Phase 2 Treatment of Anxiety and Anorexia Nervosa in Adolescents Completed
  4. Phase 2 The Role of Parathyroid Hormone (PTH) in Low Bone Mass in Anorexia Nervosa Completed
  5. Phase 2 Hormonal Factors in the Treatment of Anorexia Nervosa Completed
  6. Phase 2 Safety Profile of Insulin Like Growth Factor-1 (IGF-I) Administration in Adolescents Completed
  7. Phase 2 Olanzapine in the Treatment of Patients With Anorexia Nervosa Completed
  8. Phase 2 Effect of Growth Hormone on Bone Metabolism in Anorexia Nervosa Completed
  9. Phase 2 Transdermal Estrogen in Older Premenopausal Women With Anorexia Nervosa Completed
  10. Phase 1 Dopamine Receptor Contributions to Prediction Error and Reversal Learning in Anorexia Nervosa Completed
  11. N/A Study of Refeeding to Optimize iNpatient Gains Completed
  12. N/A Effect Of Biomechanical Stimulation On Skeletal Health In Adolescent And Young Women With Anorexia Nervosa Completed
  13. N/A Feasibility Study Comparing Standard FBT and Guided Self-Help FBT for Adolescent Anorexia Nervosa Completed
  14. N/A Shifting Perspectives: Enhancing Outcomes in Anorexia Nervosa With CRT Completed
  15. N/A Olanzapine Versus Placebo for Outpatients With Anorexia Nervosa Completed
  16. N/A IGF-1 and Bone Loss in Women With Anorexia Nervosa Completed
  17. N/A Optimizing Provider Training in Eating Disorders (OPTED) Completed
  18. N/A Evaluation of the Communities of Healing Mentorship/Support Group Program: Assessment of Preliminary Efficacy Completed
  19. N/A The Effectiveness and Mechanism Study of Auricular Needling in Treating Cancer Induced Anorexia Completed
  20. N/A Helping HAND: Healing Anorexia Nervosa Digitally Completed
  21. N/A PET Imaging Study of Recovered Anorexics Completed
  22. N/A The Role of Lactobacillus Reuteri in Children and Adolescents With Anorexia Nervosa Completed
  23. N/A Trial of Quetiapine in Anorexia Nervosa Completed
  24. N/A App-Based Mindfulness Training for Individuals With Anorexia Nervosa and Bulimia Nervosa Completed
  25. N/A Parent Emotion Coaching for Anorexia Nervosa Completed

Showing the 31 most-cited and recently-updated of 31 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Anorexia nervosa: what the trials found

Pharmacological interventions for anorexia nervosa have shown mixed results regarding physical and psychological outcomes. Fluoxetine was associated with a significant reduction in psychological symptoms as measured by the Beck Anxiety Inventory (p=0.007), though it did not result in a statistically significant change in weight per month (p=0.75) or patient retention at one year (p=0.57) 3. Risperidone showed no significant impact on reaching normal eating behaviors (p=0.55) or improving scores on the Color A Person Test (p=0.47) 4.

Evidence regarding bone health in this population is established through various hormonal and pharmacological agents. Testosterone significantly increased bone mineral density (p<0.0001) and improved markers of bone metabolism (p=0.002) 9. Physiologic estrogen/progesterone also resulted in a significant increase in spine bone density over 18 months (p<0.05) 10. Additionally, Romosozumab showed a significant positive change in lumbar spine bone mineral density at 12 months (p=<0.0001) 5, while Denosumab showed a statistically significant increase in lumbar spine bone mineral density (p=0.009) 6.

Recent results — preliminary, needs further review

  • A mobile app intervention was found to significantly improve eating disorder psychopathology as measured by the Eating Disorder Examination-Questionnaire (p=0.0003) and significantly impact Body Mass Index (p=0.0166), though it did not significantly change the number of reported eating behaviors (p=0.950) 1. Web-based training for family-based treatment did not show significant differences in completion rates, knowledge assessment scores, or the number of participants receiving consultation at 12 months 19.

For the clinician treating this condition

  • Fluoxetine is associated with a reduction in anxiety symptoms but does not significantly impact weight gain or retention in anorexia patients.
  • Hormonal therapies (Testosterone and Physiologic Estrogen/Progesterone) and specific agents like Romosozumab are effective for improving bone mineral density.

AI synthesis of 8 cited trials, updated Jun 26, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.