N/A
Completed N=7
tDCS and Cognition in Adults With Multiple Sclerosis or Encephalitis
Source: ClinicalTrials.gov NCT02538094 ↗Enrolled (actual)
7
Serious AEs
0.0%
Results posted
Apr 2020
Primary outcomePrimary: Change in Cognition as Assessed by Change in Paced Auditory Serial Addition Test Scores — -1.20; -0.33 score on a scale
Summary
This research is being done to determine whether transcranial direct current stimulation (tDCS) can improve certain mental abilities in individuals with multiple sclerosis (MS) or encephalitis. Participants will be asked to come in daily for two full weeks during which time participants will undergo cognitive testing and Magnetic Resonance Imaging (MRI) brain scans. In this research, a very weak electrical current is administered to the surface of the scalp while participants complete cognitive tasks. The investigators' aim is to find out whether tDCS will improve task performance in adults with multiple sclerosis or encephalitis.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Cognition as Assessed by Change in Paced Auditory Serial Addition Test Scores |
-1.20; -0.33 | — |
| SECONDARY Change in Fatigue as Assessed by Multidimensional Fatigue Symptom Inventory 30-item Short Form (MFSI-SF) Total Scores |
-7.40; -15.0 | — |
Eligibility Criteria
Inclusion Criteria
- Diagnosis of multiple sclerosis or encephalitis
- Over the age of 18
Exclusion Criteria
- A diagnosis of schizophrenia bipolar disorder
- Beck Depression Inventory-II scores over 20
- Mini Mental Exam below 24
- Any uncontrolled seizure disorder
- Any implanted metal device or hearing aids
- Use of medication shown to interact with tDCS effectiveness
Data sourced from ClinicalTrials.gov (NCT02538094). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.