N/A N=38 Randomized Double-blind Basic Science

Effects of Buprenorphine on Mood in Adults With a Range of Depressive Symptomatology

Depression

Bottom Line

View on ClinicalTrials.gov: NCT02659787 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

May 2019

Primary outcome: Primary: Subjective Effects as Assessed by Score on "Feel Drug", "Feel High", "Like Drug", and "Want More" Subscales of the Drug Effects Questionnaire Subjective Response With and Without Buprenorphine — 21.03; 10.64; 23.09; 19.8 units on a scale

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: 0.2mg Buprenorphine (Drug); Placebo (Drug)
Age: Adult · 18+ yrs
Sex: All
Sponsor: University of Chicago
Primary completion: Apr 2017

Outcome Measures

Outcome	Result	p-value
PRIMARY Subjective Effects as Assessed by Score on "Feel Drug", "Feel High", "Like Drug", and "Want More" Subscales of the Drug Effects Questionnaire Subjective Response With and Without Buprenorphine	21.03; 10.64; 23.09; 19.8; 10.91; 5.74	—

Summary

This study seeks to to study the effects of buprenorphine, a partial mu-opioid agonist, on depressed mood in a healthy young adults with a range of depressive symptomatology.

Eligibility Criteria

Inclusion Criteria

Healthy adult volunteers
High school education
Fluency in English
BMI between 19 and 30

Exclusion Criteria

Medical conditions contraindicating study participation
Regularly medication use
Current or past opioid abuse or dependence
Current or past drug or alcohol dependence
Psychiatric illness
Women who are pregnant or nursing

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02659787). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.