N/A N=27 Randomized Treatment

Integrated Treatment for Posttraumatic Stress Disorder and Substance Abuse in Young Adults

Substance Use Disorder · Posttraumatic Stress Disorder

Bottom Line

View on ClinicalTrials.gov: NCT02667119 ↗

Enrolled (actual)

Serious AEs

18.5%

Results posted

Sep 2022

Primary outcome: Primary: Change in Severity of Posttraumatic Stress Disorder Symptoms as Measured by the National Stressful Events PTSD Scale — 1.92; 2.61 score on a scale — p=.041

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Prolonged Exposure with Contingency Management (Behavioral); Standard Care (Behavioral)
Age: Adult · 18+ yrs
Sex: All
Sponsor: UConn Health
Primary completion: Jun 2021

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in Severity of Posttraumatic Stress Disorder Symptoms as Measured by the National Stressful Events PTSD Scale	1.64; 2.29	.016 sig
PRIMARY Change in Severity of Posttraumatic Stress Disorder Symptoms as Measured by the National Stressful Events PTSD Scale	1.64; 2.29	.016 sig
PRIMARY Longest Duration of Abstinence From Illicit Drugs (Physiological Measure - Urine Drug Screens)	4.29; 1.77	.04 sig
SECONDARY Change in Severity of Depression Symptoms as Measured by the Center for Epidemiological Studies-Depressed Mood Scale	14.64; 21.69	.043 sig
SECONDARY Change in Severity of Depression Symptoms as Measured by the Center for Epidemiological Studies-Depressed Mood Scale	14.64; 21.69	.043 sig
SECONDARY Change in Quality of Life as Measured by the Quality of Life Scale	1.44; 1.33	.508
SECONDARY Change in Quality of Life as Measured by the Quality of Life Scale	1.44; 1.33	.508

Summary

The purpose of the study is to determine the safety and efficacy of an integrated treatment for substance abuse and posttraumatic stress disorder for young adults. The integrated treatment includes two established psychosocial treatments for substance abuse (Contingency Management) and posttraumatic stress disorder (Prolonged Exposure therapy).

Eligibility Criteria

Inclusion Criteria

18-25 years old
meets diagnostic criteria for substance use disorder
meets diagnostic criteria for full or subthreshold posttraumatic stress disorder
currently able to provide a urine drug screen that is negative for cocaine, prescription opiates, and non-prescribed methadone or provided this type of screen in the past 60 days
speaks English

Exclusion Criteria

significant cognitive impairment or serious uncontrolled psychiatric problem (other than posttraumatic stress disorder)
in recovery from pathological gambling or current pathological gambling diagnosis
in a current domestic violence relationship

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02667119). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.