Meta-analysis reveals shorter telomeres in bipolar disorder versus healthy control populations across large sample sizes
Meta-analysis links bipolar disorder to shorter telomeres in a very large group
This meta-analysis of 5,639 patients with bipolar disorder and 226,358 healthy controls found significantly shorter telomere lengths. The as…
A massive analysis of nearly 60,000 people found that those with bipolar disorder had shorter telomeres than healthy controls.
Bipolar disorder is associated with a 3.65-fold higher risk of Parkinson's disease in six cohort studies
People with bipolar disorder face higher risk of developing Parkinson's disease based on recent analysis
This meta-analysis of six cohort studies evaluated the incidence of Parkinson's disease in individuals with bipolar disorder. The pooled ana…
A review of six studies found people with bipolar disorder have a much higher chance of getting Parkinson's disease. However, experts say we…
Cocaine use disorder prevalence in bipolar disorder is 10.94 percent with worse clinical outcomes
One in ten people with bipolar disorder also struggles with cocaine use
This systematic review and meta-analysis of 6,150,881 individuals with bipolar disorder found a pooled overall prevalence of cocaine use dis…
A large review found that 11 percent of people with bipolar disorder also have cocaine use disorder, a number that jumps to 46 percent in sp…
GLP-1RAs reduce weight and HbA1c in severe mental illness with low discontinuation rates
New drugs help people with severe mental illness lose weight safely
This systematic review and meta-analysis evaluated glucagon-like peptide-1 receptor agonists in individuals with severe mental illness who h…
New weight loss drugs work well and stay safe for people with severe mental illness who struggle with obesity and high blood sugar.
Diffusion tensor imaging shows lower fractional anisotropy in bipolar disorder white matter tracts
Bipolar Brain Wiring Shows Clear Damage in Key Emotional Pathways
This systematic review and meta-analysis of diffusion tensor imaging studies compared 5,372 individuals with bipolar disorder to 6,240 healt…
Brain scans reveal consistent white matter damage in bipolar disorder, especially in tracts that regulate emotion and connect brain hemisphe…
Meta-analysis finds decreased GDNF levels in bipolar disorder but high heterogeneity limits conclusions
Brain chemical levels differ in bipolar disorder compared to healthy people
This meta-analysis of 825 patients with bipolar disorder (BD) and 885 healthy controls found significantly lower circulating GDNF levels in …
A large review found lower levels of a specific brain chemical in people with bipolar disorder. This difference was clear even when comparin…
Meta-analysis reviews psychosis prevalence in bipolar disorder patients across 285 studies
Psychosis common in bipolar disorder, review finds
This meta-analysis reviews data from 285 studies regarding the prevalence of psychosis and psychotic symptoms in patients with bipolar disor…
Nearly half of people with bipolar disorder experience psychosis, and 8% also have schizophrenia, a review of 285 studies finds.
Narrative review explores microbiome mechanisms as a promising adjunctive avenue for managing depression, anxiety, bipolar disorder, and schizophrenia
Gut Bacteria Can Change Your Mood
This narrative review examines how microbiome-driven modulation of neurotransmitters, microbial metabolites, immune activation, and vagal ne…
What if the bacteria in your gut could be quietly shaping how you feel every day — and fixing them could ease anxiety or depression?
Observational study identifies sensory perception differences in schizophrenia and first-episode psychosis
Simple tests reveal unique sensory signs for early psychosis types
This observational study investigated psychophysical differences in pictorial size perception and auditory discomfort among patients with sc…
New low-cost tests can spot unique sensory changes that help doctors tell schizophrenia apart from bipolar disorder in early psychosis cases…
Parental severe mental illness associated with reduced offspring cognitive and academic performance in large meta-analysis
Children of parents with mental illness face real cognitive hurdles now
This meta-analysis examined 1,586,339 offspring of parents with severe mental illnesses, including schizophrenia, bipolar disorder, and majo…
New research shows kids of parents with severe mental illness struggle with memory and thinking skills, but early help can make a big differ…
Narrative review examines multidisciplinary strategies for metabolic syndrome in bipolar disorder
Half of Bipolar Patients Face Hidden Heart Risks
This narrative review explores multidisciplinary monitoring and treatment strategies, including lifestyle and pharmacological approaches, fo…
Imagine living with bipolar disorder. You manage your mood swings with medication and therapy.
Blood biomarker variance in UK Biobank influenced by technical, demographic, and behavioral factors
Why Blood Tests Fail to Predict Mental Health
This UK Biobank cohort study examined how technical, demographic, behavioral, and temporal factors influence 29 blood biomarkers.
Many doctors rely on blood work to check your physical health.
Questions about Bipolar Disorder
Can changes in gut bacteria help manage symptoms of bipolar disorder and depression?
Early research shows gut bacteria differ in people with bipolar disorder and depression, but it's too soon to say whether changing gut bacteria can manage symptoms.
Full answer →Are there lower levels of GDNF in the blood of people with bipolar disorder?
Research suggests GDNF levels may be lower in people with bipolar disorder, especially during manic episodes, but findings are mixed and not definitive.
Full answer →What does the research say about psychosis rates in people with bipolar disorder?
A large meta-analysis found that about 47% of people with bipolar disorder experience mood-incongruent psychosis, and psychotic symptoms are common, especially in bipolar I disorder.
Full answer →All Bipolar Disorder Articles
- Meta-analysis reveals shorter telomeres in bipolar disorder versus healthy control populations across large sample sizes
- Bipolar disorder is associated with a 3.65-fold higher risk of Parkinson's disease in six cohort studies
- Cocaine use disorder prevalence in bipolar disorder is 10.94 percent with worse clinical outcomes
- Diffusion tensor imaging shows lower fractional anisotropy in bipolar disorder white matter tracts
- GLP-1RAs reduce weight and HbA1c in severe mental illness with low discontinuation rates
- Meta-analysis finds decreased GDNF levels in bipolar disorder but high heterogeneity limits conclusions
- Meta-analysis reviews psychosis prevalence in bipolar disorder patients across 285 studies
- Observational study identifies sensory perception differences in schizophrenia and first-episode psychosis
- Narrative review explores microbiome mechanisms as a promising adjunctive avenue for managing depression, anxiety, bipolar disorder, and schizophrenia
- Parental severe mental illness associated with reduced offspring cognitive and academic performance in large meta-analysis
- Blood biomarker variance in UK Biobank influenced by technical, demographic, and behavioral factors
- Narrative review examines multidisciplinary strategies for metabolic syndrome in bipolar disorder
- Multi-omics data integration in Spanish psychiatric patients and controls
- Mendelian randomization suggests loneliness causally increases schizophrenia and major depressive disorder risk
- Cross-trait analyses reveal complex genetic overlaps between cortical morphology and psychiatric disorders
- Meta-analysis finds gamma neuromodulation benefits in schizophrenia and major depressive disorder
- Plasma NfL levels elevated in bipolar and depressive disorders in UK Biobank cohort
- FDA Approves Lamotrigine Tablets (lamotrigine) for Epilepsy and Bipolar Disorder Maintenance
- Mental health syndemics reduce ART adherence and impair viral suppression in people living with HIV
- Hypoxia-cognition training showed no significant effects on prefrontal or hippocampal microstructure in remitted mood disorder patients
- Social risk factors show larger effect sizes than polygenic risk scores for bipolar disorder in cohort study
- Protocol outlines target trial emulation for bipolar disorder treatments in patients with opioid use disorder
- FDA Approves Lamotrigine for Adjunctive Therapy in Epilepsy and Maintenance in Bipolar I Disorder
- FDA Approves Depakote ER (divalproex sodium) for Acute Manic or Mixed Episodes in Bipolar Disorder
- FDA Approves Depakote (divalproex sodium) for Manic Episodes Associated with Bipolar Disorder
- Meta-analysis identifies distinct and shared amygdala connectivity patterns in major depression and bipolar disorder
- Transcriptomic meta-analysis in bipolar disorder identifies mitochondrial, synaptic, and inflammatory pathway genes
- Insomnia's association with cognitive function studied in 170 bipolar disorder outpatients