GLP-1RAs reduce weight and HbA1c in severe mental illness with low discontinuation rates
New drugs help people with severe mental illness lose weight safely
This systematic review and meta-analysis evaluated glucagon-like peptide-1 receptor agonists in individuals with severe mental illness who h…
New weight loss drugs work well and stay safe for people with severe mental illness who struggle with obesity and high blood sugar.
Meta-analysis finds decreased GDNF levels in bipolar disorder but high heterogeneity limits conclusions
Brain chemical levels differ in bipolar disorder compared to healthy people
This meta-analysis of 825 patients with bipolar disorder (BD) and 885 healthy controls found significantly lower circulating GDNF levels in …
A large review found lower levels of a specific brain chemical in people with bipolar disorder. This difference was clear even when comparin…
Meta-analysis reviews psychosis prevalence in bipolar disorder patients across 285 studies
Psychosis common in bipolar disorder, review finds
This meta-analysis reviews data from 285 studies regarding the prevalence of psychosis and psychotic symptoms in patients with bipolar disor…
Nearly half of people with bipolar disorder experience psychosis, and 8% also have schizophrenia, a review of 285 studies finds.
Narrative review explores microbiome mechanisms as a promising adjunctive avenue for managing depression, anxiety, bipolar disorder, and schizophrenia.
Gut Bacteria Can Change Your Mood
This narrative review examines how microbiome-driven modulation of neurotransmitters, microbial metabolites, immune activation, and vagal ne…
What if the bacteria in your gut could be quietly shaping how you feel every day — and fixing them could ease anxiety or depression?
Observational study identifies sensory perception differences in schizophrenia and first-episode psychosis
Simple tests reveal unique sensory signs for early psychosis types
This observational study investigated psychophysical differences in pictorial size perception and auditory discomfort among patients with sc…
New low-cost tests can spot unique sensory changes that help doctors tell schizophrenia apart from bipolar disorder in early psychosis cases…
Parental severe mental illness associated with reduced offspring cognitive and academic performance in large meta-analysis
Children of parents with mental illness face real cognitive hurdles now
This meta-analysis examined 1,586,339 offspring of parents with severe mental illnesses, including schizophrenia, bipolar disorder, and majo…
New research shows kids of parents with severe mental illness struggle with memory and thinking skills, but early help can make a big differ…
Narrative review examines multidisciplinary strategies for metabolic syndrome in bipolar disorder
Half of Bipolar Patients Face Hidden Heart Risks
This narrative review explores multidisciplinary monitoring and treatment strategies, including lifestyle and pharmacological approaches, fo…
Imagine living with bipolar disorder. You manage your mood swings with medication and therapy.
Blood biomarker variance in UK Biobank influenced by technical, demographic, and behavioral factors
Why Blood Tests Fail to Predict Mental Health
This UK Biobank cohort study examined how technical, demographic, behavioral, and temporal factors influence 29 blood biomarkers. Variance e…
Many doctors rely on blood work to check your physical health.
Multi-omics data integration in Spanish psychiatric patients and controls
Scientists Are Building a Mental Health Database That Could Change Treatment Forever
This cohort study in Spain involved over 4,400 participants, including approximately 2,300 psychiatric patients and 2,100 controls. The rese…
This project could finally help doctors match the right treatment to the right patient, reducing the trial-and-error that many people face t…
Meta-analysis finds gamma neuromodulation benefits in schizophrenia and major depressive disorder
Gamma neuromodulation showed symptom improvements in schizophrenia and depression in this review
This systematic review and meta-analysis synthesizes evidence on gamma neuromodulation for neuropsychiatric disorders. It reports moderate i…
Gamma neuromodulation improved positive and negative symptoms, anxiety, and thinking skills in schizophrenia while reducing depression in ma…
Mendelian randomization suggests loneliness causally increases schizophrenia and major depressive disorder risk.
Feeling Alone May Quietly Rewire Your Mental Health
This Mendelian randomization study investigated the causal relationship between loneliness and severe mental illness, including schizophreni…
Loneliness may directly raise the risk of schizophrenia and depression by changing body chemistry through inflammation, affecting millions o…
Cross-trait analyses reveal complex genetic overlaps between cortical morphology and psychiatric disorders.
Your Brain's Blueprint May Not Predict Mental Illness After All
This cross-trait analysis examined genetic loci shared between cortical surface area or thickness and various psychiatric conditions. Result…
Brain shape genes and mental illness genes often push in opposite directions, complicating hopes for using scans and DNA to predict conditio…