N/A
N=20
Remediation of Auditory Recognition in Schizophrenia With tDCS
Schizophrenia · Schizoaffective Disorder
Bottom Line
View on ClinicalTrials.gov: NCT02869334 ↗Enrolled (actual)
20
Serious AEs
0.0%
Results posted
Jul 2021
Primary outcome: Primary: Auditory Tone Matching Task — -4.3; 4.8 %correct, different trials
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Active Transcranial direct current stimulation (tDCS) (Device); Sham Transcranial direct current stimulation (tDCS) (Device); Auditory Remediation (Behavioral); Control computer activities (Behavioral)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- New York State Psychiatric Institute
- Primary completion
- Jan 2020
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Auditory Tone Matching Task |
-4.3; 4.8 | — |
| SECONDARY Auditory Emotion Recognition (AER) Task |
-3.0; 5.1 | — |
| SECONDARY ER-40 |
-5.0; -1.3 | — |
| SECONDARY The Awareness of Social Inference Test (TASIT) |
10; 0 | — |
| SECONDARY Auditory Mismatch Negativity (MMN) |
-1.47; -.98 | — |
Summary
The purpose of this study is to determine whether transcranial direct current stimulation (tDCS), when combined with different forms of computer based training, improves the ability to discriminate small differences between sounds in people diagnosed with schizophrenia or schizoaffective disorder.
Eligibility Criteria
Inclusion Criteria
- Age 18-55
- Primary diagnosis of Schizophrenia or schizoaffective disorder
- English fluency
- Willing/capable to provide informed consent
- Auditory tone matching deficits
- Receiving stable doses of antipsychotic medication(s) for at least 2 weeks
- IQ>75
Exclusion Criteria
- Serious neurological disorder or medical condition/ treatment known to affect the brain. Neurological Disorder that affects the central nervous system (CNS), such as epilepsy, neurodegenerative disorders, movement disorders and sensory disorders.
- Current or past history (within the last 6 months) of substance abuse or dependence (excluding nicotine)
- Pregnancy or breastfeeding
- Taking anticholinergic medication (e.g. Cogentin, Thorazine, Clozaril, thioridazine)
Data sourced from ClinicalTrials.gov (NCT02869334). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.