N/A N=42 Treatment

Ecological Effect of Arginine Dentifrice on Oral Microbiota

Dental Caries · Oral Bacterial Infection · Microbiota

Bottom Line

View on ClinicalTrials.gov: NCT02988349 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Nov 2018

Primary outcome: Primary: The Change of Abundance of Specific Oral Microbes After Intervention as Assessed by 16S rRNA Sequencing — 0.00756; 0.14636; 0.00629; 0.11956 percentage of bacteria

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Colgate® Sensitive Pro-Relief® toothpaste (Other)
Age: Pediatric, Adult, Older Adult
Sex: All
Sponsor: Sichuan University
Primary completion: Jul 2014

Outcome Measures

Outcome	Result	p-value
PRIMARY The Change of Abundance of Specific Oral Microbes After Intervention as Assessed by 16S rRNA Sequencing	0.00756; 0.14636; 0.00629; 0.11956; 0.00608; 0.01314	—
SECONDARY The Change of Relative Activities of Microbial Enzymes After Intervention as Determined by Laboratory Enzymatic Assays	0.8945; 0.3653; 0.63150; 0.29110; 0.75870; 0.23470	—

Summary

caries-free (CF) individuals caries-active (CA) individuals (DMFT ≥ 6) will be recruited. Subjects will be instructed to brush their teeth twice daily for 3 min using Colgate® Sensitive Pro-Relief® toothpaste (containing 8% arginine and 1450 ppm NaF) for 2 weeks. Supra- and subgingival plaque, saliva, and in situ plaque samples will be collected before and after the treatment for laboratory analyses.

Eligibility Criteria

Inclusion Criteria

caries-free individuals with no clinical evidence of caries experience [decayed, missing and filled teeth (DMFT) = 0] and caries-active individuals (DMFT ≥ 6) were recruited

Exclusion Criteria

smoker or former smoker, presence of any systemic disease that could alter the production or composition of saliva, treatment with antibiotics, steroids or any medication known to cause dry mouth in the last 3 months, and presence of dental prostheses or orthodontic devices.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02988349). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.