Clinical Trial Search

Primary: Total Net D12FS Caries Increment (Total of Non-cavitated Lesions (D1), Cavitated Lesions (D2) and Sound Surfaces (S)) — 2.43; 2.68 weighted increment units/13 months…

Primary: Number of Participants With Arrested Dental Caries, Assessed Using a Clinical Oral Examination — 48; 53 Participants

Primary: Proportion of Subjects With All Caries Arrested — 108; 101 Participants

Primary: ICDAS Severity Value — 17; 22; 278; 273 teeth — p=0.1126

Primary: Percent Surface Microhardness (SMH) Recovery of Enamel Specimens Exposed to NaF Toothpaste (1426ppmF) and AmF Toothpaste (1400ppmF) — 38.05; 41.06 Percentage SMHR…

Primary: Percentage of Participants Who Indicate Surgical Intervention — 74 percentage of the dentists

Primary: Percentage Surface Microhardness Recovery (%SMHR) of Sound Enamel Specimens Exposed to NaF Toothpaste (1450ppmF) and NaF Toothpaste (1400ppmF) — 28.31; 26.32 Percentage…

Primary: Change in Streptococcus Mutans Levels in Dental Plaque — 3.11; 0.93; 1.91; 2.23 log10CFU/g — p=0.123

Primary: Mean Percentage Surface Microhardness Recovery (%SMHR) of Enamel Specimens Exposed to NaF/Carbopol Toothpaste (1400 ppmF), NaF Toothpaste (1350ppmF) Compared to…

Primary: the Mean Number of Enamel Carious Lesion — 13.69; 14.55 Surfaces

Primary: Antimicrobial Activity of C16G2 — -0.2; -0.04; 0.005; 0.15 CFU/mL

Primary: Number of Lesions Showing Radiographic Progression as Measured by Lesion Size (Continuous) — 2; 11 Lesions — p=0.002

Primary: Number of Participants With Treatment Failure — 2; 2 participants

Primary: Root Caries Activity — 3.72; 40.52 Percentage of active lesions (2-years)

Primary: Number of New Tooth Root Caries Lesions — 1.1; 0.43; 0.56 new carious root surfaces

Primary: Percentage Surface Micro-hardness Recovery (SMHR) of Enamel Specimens — 39.46; 38.31; 36.17; 17.26 % SMHR — p=0.7756

Primary: Caries Activity and Progression Assessment Using LASER Fluorescence Readings by Diagnodent® Device. — 18.6; 1.1 units on a scale

Primary: Change in the Number of Decayed or Filled Permanent Teeth (DFT) From Baseline (Beginning of Kindergarten) to the Middle of 2nd Grade — 0.38; 0.48 Number of surfaces…

Primary: Safety of Multiple C16G2 Varnish Applications — 0; 0; 0; 0 Participants

Primary: Change in White Spot Lesions Count - Enamel Decalcification Index (EDI) — 40.2; 41.3 units on a scale

Primary: Presence or Absence of Elevated Luminescence — 61.7; 17.3; 6.0; 10.2 % active teeth with luminescence

Primary: The Change of Abundance of Specific Oral Microbes After Intervention as Assessed by 16S rRNA Sequencing — 0.00756; 0.14636; 0.00629; 0.11956 percentage of bacteria

Primary: Mineral Loss ΔZ — 235; 774 vol% * μm]

Primary: Evaluation of Decayed, Missing, and Filled Tooth Surfaces (Dmfs) at Baseline — 19.9; 22.8 dmfs

Primary: Percentage Surface Microhardness Recovery (%SMHR) of Placebo Dentifrice/Fluoride Rinse Compared to Placebo Dentifrice/No Rinse — 24.48; 8.09 % SMHR — p=<0.0001

Primary: Clinical Outcome Based on Success After Intervention on MIH Affected Molar at 6 Months — 17; 18; 17 number of Successful MIH affected molars

Primary: Percentage Surface Microhardness Recovery (SMHR) of Phyte (0% 0.425% and 0.85%) at 2 Weeks — 25.53; 26.81; 7.41; 28.88 % SMHR — p=0.7603

Primary: Caries Increment — 9.8; 11.3 Number of tooth surfaces — p=0.279

Primary: Evaluation of the Concentration of Fluoride Incorporated Into the Biofilm Done 6 Months After Initiation of Dentifrices Use. — 0.80; 1.32; 1.74 mmol/kg — p=<0.05

Primary: Dental Plaque Levels Measures on Scale of 0-2 — 0.391 units on a scale