N/A
N=51
Passive Mobilization and Vascular Function
Endothelial Dysfunction · Aging · Bed Rest
Bottom Line
View on ClinicalTrials.gov: NCT03087643 ↗Enrolled (actual)
51
Serious AEs
0.0%
Results posted
Aug 2019
Primary outcome: Primary: Change of Delta Peak Blood Flow During sPLM — 91.9; -24.7 ml/min — p=0.0492
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Passive mobilization - PM (Other)
- Age
- Older Adult · 65+ yrs
- Sex
- All
- Sponsor
- Universita di Verona
- Primary completion
- Jun 2017
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change of Delta Peak Blood Flow During sPLM |
91.9; -24.7 | 0.0492 sig |
| PRIMARY Change of % FMD |
0.2; 0.0 | 0.0283 sig |
| SECONDARY Change of Total Hemoglobin |
-12.5; -2.2 | 0.0321 sig |
| SECONDARY Change of Range of Motion |
13.13; 3.93 | 0.0451 sig |
| SECONDARY Change of Thickness of Vastus Lateralis |
0.53; 0.25 | 0.0476 sig |
Summary
With aging, vascular function (VF) declines. Inactivity and sedentary life style have been shown to contribute to the worsening of VF. Furthermore, bed rest, a condition commonly used for the management of many chronic conditions, has been proven to lead to even more deleterious consequences, including VF decline.
This study evaluates the effect of passive mobilization of the lower limbs on VF in bedridden oldest-old. Half of the participants will undergo passive mobilization treatment in addition to standard therapies, while the other half will receive only standard therapies. We hypothesize that passive mobilization may improve nitric oxide (NO)-mediated endothelial function.
Eligibility Criteria
Inclusion Criteria
- Bedridden
Exclusion Criteria
- Neurodegenerative disease (i.e.Parkinson's disease, Alzheimer's disease)
- Heart failure
- Organ transplantation
- Liver failure
- Kidney failure
- Hemorrhage
- Neuromuscular diseases
Data sourced from ClinicalTrials.gov (NCT03087643). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.