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N/A N=1,918 Randomized Single-blind Prevention

FluSAFE: Flu SMS Alerts to Freeze Exposure

Influenza · Acute Respiratory Infection · Influenza-like Illness

Enrolled (actual)
1,918
Serious AEs
0.0%
Results posted
Jan 2025
Primary outcome: Primary: Number of Laboratory-confirmed Influenza Infections — .22; .14 infections

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
Educational text messages (Behavioral)
Age
Pediatric, Adult, Older Adult
Sex
All
Sponsor
Columbia University
Primary completion
Mar 2021

Outcome Measures

OutcomeResultp-value
PRIMARY
Number of Laboratory-confirmed Influenza Infections
.22; .14
SECONDARY
Number of Cases of Household Members Meeting Symptomatic Criteria for ILI/ARI
.20; .19
SECONDARY
Number of Infections of Non-influenza Respiratory Viruses
.27; .23

Summary

Influenza infection results in an estimated 31 million outpatient visits, 55,000 to 974,200 hospitalizations, and 3,000 to 49,000 deaths. Membership in household in which someone else has influenza is the major risk factor for contracting influenza. The household secondary attack rate (SAR) is as high as 19% based on laboratory-confirmed influenza and 30% based on symptoms. Non-pharmaceutical preventive measures, including education, may play a role in decreasing transmission, but are only effective if started within 36 hours of symptom onset in index cases. Yet, most interventions are delayed because they are not initiated until care is sought. The investigators have demonstrated in one primarily Latino, urban community sample, that text messaging can be used to rapidly identify community members with influenza-like illness (ILI) early in an illness. This early identification would enable implementation of an educational intervention in the optimal time frame to reduce influenza transmission. Providing education within a text message is a proven successful strategy to influence behavior. Text messaging itself is scalable, low-cost, and can be used in low literacy populations. However, using text-message based surveillance to trigger a real-time text-message behavioral educational intervention to decrease household influenza transmission has not been assessed.

Eligibility Criteria

Inclusion Criteria

  • ≥3 persons per household
  • At least one person who is less than 18 years old
  • English or Spanish speaking
  • Household reporter has cell phone with text messaging capabilities
  • Household reporter willing to use text messages to report
  • Reside within study neighborhoods in New York City

Exclusion Criteria

  • Intention to move away from New York City area in <12 months
  • Language other than English or Spanish
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03274310). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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