Mode
Home
Research
Clinical Trials Drug Pipeline Weekly Digests
Reference
Conditions Medications
Community
Questions
Text Size
Log in / Sign up
Home › Conditions › Respiratory Disease

Respiratory Disease

21 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Respiratory Disease

28 trials tracked for Respiratory Disease: 5 in phase 3 or 4 and 3 with published results. The most-cited published study has 431 citations.

28Trials tracked
5Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 3 Phase 3 2 Phase 2 8 Phase 1 3 Other / NA 12
  1. Phase 3 Outcomes Related to COVID-19 Treated With Hydroxychloroquine Among In-patients With Symptomatic Disease Completed · 431 cited
  2. Phase 4 Roflumilast in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Fixed Dose Combinations of Long-acting β2-agonist (LABA) and Inhaled Corticosteroid (ICS) Completed · 125 cited
  3. Phase 4 The Study of the Use of Nintedanib in Slowing Lung Disease in Patients With Fibrotic or Non-Fibrotic Interstitial Lung Disease Related to COVID-19 Completed · 1 cited
  4. Phase 4 Treatment of Acute Sinusitis Completed
  5. Phase 3 Efficacy and Safety of Polyoxidonium, Nasal and Sublingual Spray, 6 mg/ml in Children Aged 1-12 Years With ARI Completed
  6. Phase 2 Evaluation of the Effect of AZD5069 in Patients With Bronchiectasis Completed
Show 22 more trials
  1. Phase 2 A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of GlaxoSmithkline (GSK) Biologicals' Investigational Vaccine GSK2838504A When Administered to Chronic Obstructive Pulmonary Disease (COPD) Patients With Persistent Airflow Obstruction. Completed
  2. Phase 2 Study to Assess the Immunogenicity and Safety of GSK's Investigational Vaccine (GSK3277511A) When Given to Healthy Smokers and Ex-smokers After Administration of Shingrix Vaccine Completed
  3. Phase 2 Vitamin D for Sickle-cell Respiratory Complications Completed
  4. Phase 2 A Study to Test if a Third Dose of the Vaccine is Safe in Current and Former Smokers Aged 40 to 80 Years Old and to Gather Information on the Immune Response Following the Third Dose of the Vaccine Completed
  5. Phase 2 A Study to Test if the Vaccine is Working Well in Chronic Obstructive Pulmonary Disease (COPD) Patients Aged 40 to 80 Years Old to Reduce Episodes of Worsening Symptoms and to Gather Further Information on Safety and Immune Response. Completed
  6. Phase 2 University of Wisconsin Meditation & Exercise Cold Study Completed
  7. Phase 2 Evaluating the Effect of Mucinex 1200mg on Mucociliary and Cough Clearance During an Acute Respiratory Infection Completed
  8. Phase 1 A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of the Investigational GSK Biologicals' GSK3277511A Vaccine in Adults. Completed
  9. Phase 1 A Long Term Follow-up Study up to 4 Years After Study Vaccination to Assess Immunogenicity and Safety of the Investigational Vaccine in Adults Completed
  10. Phase 1 Study to Evaluate the AIO-001 in Healthy Participants Completed
  11. N/A A Study to Assess Immunity to Specific Microbial Antigens in Healthy Smokers and Non-smokers and in Subjects With Stable COPD Completed
  12. N/A Infectious Pathogens in Acute Respiratory Illness in Adults and Elderly Completed
  13. N/A Utility of Continuous Pulse Oximetry for Pediatric Patients With Stable Respiratory Illness Completed
  14. N/A Prophylactic Efficacy of Relenza Against Influenza A and B Completed
  15. N/A Urgent Care Management of Respiratory Illness Enabled With Novel Testing Pathway Completed
  16. N/A Initial Specialist Telephone Consultation With New Patients in Secondary Care Completed
  17. N/A Comparing 6-Minute Walk Tests for Ambulatory Oxygen Assessment Completed
  18. N/A A Comparative Clinical Trial of the TensorTip, a Novel Non Invasive Device for Measurement Blood Parameters Completed
  19. N/A Engineering Evaluation of the Helix Ventilator Completed
  20. N/A Timing of Planned Caesarean Section and Morbidity of the Newborn Completed
  21. N/A Occurrence of Potential Bacterial and Viral Pathogens in Stable Chronic Obstructive Pulmonary Disease and During Acute Exacerbations of the Disease, in Asia Pacific Completed
  22. N/A FluSAFE: Flu SMS Alerts to Freeze Exposure Completed

Showing the 28 most-cited and recently-updated of 28 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Respiratory Disease: what the trials found

Nintedanib was evaluated for its impact on lung imaging and weight loss in patients with respiratory disease, showing a reduction in Chest CT Visual Scores (-4.49 and -4.06) and no instances of 10% weight loss at 90 or 180 days 1. Polyoxidonium (6 mg/ml) demonstrated significant efficacy in reducing fever duration (p<0.05), improving intoxication symptoms as measured by the Symptom Assessment Scale (p<0.05), and reducing nasal discharge symptoms (p<0.05) 6.

In the context of COPD, Roflumilast did not show a statistically significant effect on the rate of moderate or severe exacerbations (p=0.1634), nor on the rate of severe exacerbations leading to hospitalization or death (p=0.6354) 3. Similarly, an investigational NTHi/Mcat vaccine (GSK3277511A) showed no significant difference in the rate of moderate and severe AECOPD over a one-year period compared to control groups (p=0.8157) 9. Safety data for this vaccine indicated specific counts of local and general adverse events across different schedules 10.

Other findings include that Acetaminophen did not significantly impact SNOT-16 scores at Day 3 (p=0.83) 4. Hydroxychloroquine was evaluated in COVID patients, with consistent outcomes observed on the COVID Outcomes Scale and COVID Ordinal Outcomes Scale at various intervals post-randomization 5.

Recent results — preliminary, needs further review

  • * A study on Maximal 6-minute Walk Test (Max_6MWT) found that while there was no significant difference in the time taken to reach SpO2 nadir (p=0.50), there were significant differences in average drop in SpO2 from baseline and the Nadir SpO2 percentage between maximal and normal walking speeds (p<0.01) 2. * A Phase 1 trial for AIO-001 was recently conducted 15.

For the clinician treating this condition

  • Nintedanib is associated with improved Chest CT Visual Scores in patients with respiratory disease 1.
  • Polyoxidonium (6 mg/ml) significantly reduces fever duration and improves symptoms related to nasal discharge and intoxication 6.
  • Roflumilast and the NTHi/Mcat vaccine (GSK3277511A) did not show statistically significant differences in exacerbation rates for COPD patients in the studied trials [3, 9].

AI synthesis of 9 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Pneumococcal conjugate vaccines reduce antimicrobial resistance through direct suppression and reduced antibiotic exposure
Allergy & Immunology Sys. Review
Pneumococcal conjugate vaccines reduce antimicrobial resistance through direct suppression and reduced antibiotic exposure Pneumococcal Vaccines May Help Reduce Antibiotic Resistance in Infections
This mini review examines the impact of pneumococcal conjugate vaccines (PCVs) on antimicrobial resistance dynamics and serotype replacement…
New research highlights how pneumococcal vaccines can help lower antibiotic resistance by reducing the need for treatment and limiting resis…
Frontiers Jul 24, 2026
Point-of-care smell testing serves as an effective screening tool for various neurodegenerative and respiratory conditions
Allergy & Immunology Sys. Review
Point-of-care smell testing serves as an effective screening tool for various neurodegenerative and respiratory conditions Point of Care Smell Testing Helps Identify Clinical Needs
This narrative review synthesizes the clinical utility of point-of-care olfactory tests across neurology, primary care, and otorhinolaryngol…
New research highlights how quick smell tests can serve as effective screening tools for patients with respiratory, neurological, and psychi…
Frontiers Jun 26, 2026
Climate change drives increased frequency of vector-borne diseases through expansion of endemic areas
Infectious Disease Sys. Review
Climate change drives increased frequency of vector-borne diseases through expansion of endemic areas Climate change increases risk of heart and respiratory diseases
This narrative review synthesizes the public health consequences of global warming and climate change. The authors argue that rising tempera…
Rising global temperatures are expanding the reach of infectious diseases and creating new risks for heart, lung, and mental health.
Frontiers Jun 24, 2026
Mid-turbinate swabs match nasopharyngeal swab sensitivity for any respiratory virus in children
Infectious Disease Meta-analysis
Mid-turbinate swabs match nasopharyngeal swab sensitivity for any respiratory virus in children Mid-turbinate swabs match the gold standard for catching kids respiratory viruses
This systematic review and meta-analysis evaluated diagnostic accuracy of nasopharyngeal aspirates, mid-turbinate swabs, anterior nasal swab…
Mid-turbinate swabs match the gold standard for catching kids respiratory viruses while being far more comfortable than the current method.
medRxiv Jun 3, 2026
Respiratory microbiome composition in children offers new ideas for precision treatment of respiratory diseases and asthma
Pulmonology & Critical Care Sys. Review
Respiratory microbiome composition in children offers new ideas for precision treatment of respiratory diseases and asthma New ideas for treating children with asthma and respiratory infections
This narrative review examines the respiratory microbiome, metabolites, and colonization in children with respiratory infections, allergic a…
This review offers fresh directions for understanding how the respiratory microbiome affects children with asthma and allergic airway inflam…
Frontiers May 29, 2026
Host factors influence viral entry and replication in HPIV infected infants, elderly, and immunocompromised individuals
Genetics & Precision Medicine Sys. Review
Host factors influence viral entry and replication in HPIV infected infants, elderly, and immunocompromised individuals Host factors influence how the parainfluenza virus infects vulnerable people
This narrative review discusses host factors influencing viral entry, replication, assembly, release, and innate immunity evasion in human p…
A review explains how host factors affect viral entry and immunity in infants, the elderly, and immunocompromised individuals with respirato…
Frontiers May 29, 2026
Systematic review maps 50 most-cited articles on pediatric respiratory infections
Pediatrics Sys. Review
Systematic review maps 50 most-cited articles on pediatric respiratory infections Most cited research on child respiratory infections comes from US, China, Canada
This systematic bibliometric review analyzed the 50 most-cited articles on pediatric respiratory infections. Key findings show a predominanc…
A review of 50 top-cited articles on pediatric respiratory infections shows most research comes from just three countries.
medRxiv May 22, 2026
Review synthesizes potential uses of Fritillariae Cirrhosae Bulbus alkaloids for various conditions
Drug Pipeline Sys. Review
Review synthesizes potential uses of Fritillariae Cirrhosae Bulbus alkaloids for various conditions Alkaloids from Fritillariae Cirrhosae Bulbus show promise for multiple health conditions
This narrative review evaluates the potential applications of alkaloids derived from Fritillariae Cirrhosae Bulbus. The authors synthesize e…
A review suggests alkaloids from Fritillariae Cirrhosae Bulbus may help with respiratory diseases, tumors, and hypertension, though more res…
Frontiers May 20, 2026
Narrative review evaluates Oxford Nanopore sequencing for pediatric infectious disease diagnostics
Infectious Disease Sys. Review
Narrative review evaluates Oxford Nanopore sequencing for pediatric infectious disease diagnostics New Pocket Device Finds Kids' Infections in Hours Not Days
This narrative review examines the use of Oxford Nanopore Technologies (ONT) sequencing in pediatric emergency infectious diseases. The auth…
• Real-time gene sequencing spots infections and antibiotic needs fast • Helps doctors treat seriously sick children in emergency rooms • St…
Frontiers May 8, 2026
Tai Chi reduces inflammatory gene expression in chronic disease patients
Oncology Meta-analysis
Tai Chi reduces inflammatory gene expression in chronic disease patients Tai Chi Calms Inflammation Genes in Chronic Disease Patients
A meta-analysis of 20 studies shows Tai Chi significantly downregulates pro-inflammatory genes like IL-6 and IL-1β in adults with chronic di…
A new review shows Tai Chi may quiet the body's inflammatory genes that drive chronic disease symptoms in adults.
Frontiers May 6, 2026
Perspective review discusses chronic air pollution effects on children and older adults in Puerto Rico
Primary Care & Family Medicine Sys. Review
Perspective review discusses chronic air pollution effects on children and older adults in Puerto Rico Air pollution may change your body’s microbes and raise cancer risk
This perspective review examines the impact of chronic air pollution and environmental exposures on children and older adults.
Tiny particles in the air we breathe may be altering the body’s microbiome and increasing cancer risk, especially in kids and older adults l…
Frontiers May 1, 2026
Effort Re-education Programme improves functionality in oncology patients with respiratory symptoms
Oncology RCT
Effort Re-education Programme improves functionality in oncology patients with respiratory symptoms Effort Re-education Programme improves function for oncology patients
In this stratified randomised clinical trial of 65 oncology patients, an Effort Re-education Programme (ERP) delivered after hospital discha…
A new breathing program may help oncology patients regain independence and reduce shortness of breath after leaving the hospital.
Apr 30, 2026

Questions about Respiratory Disease

Do cohort studies show clinical outcomes for pediatric acute respiratory infections?

Yes, cohort studies are the most common study type in pediatric ARI research, providing key data on pathogen profiles, co-infections, seasonal patterns, and clinical outcomes like hospitalization and severity.

Full answer →
How does chronic air pollution affect children and older adults in Puerto Rico?

Chronic air pollution in Puerto Rico increases risks of cancer, respiratory, and cardiovascular diseases, especially in children and older adults, through microbiome disruption and immune dysregulation.

Full answer →

All Respiratory Disease Articles