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Home › Conditions › Respiratory Disease

Respiratory Disease

17 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Respiratory Disease

28 trials tracked for Respiratory Disease: 5 in phase 3 or 4 and 3 with published results. The most-cited published study has 430 citations.

28Trials tracked
5Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 3 Phase 3 2 Phase 2 8 Phase 1 3 Other / NA 12
  1. Phase 3 Outcomes Related to COVID-19 Treated With Hydroxychloroquine Among In-patients With Symptomatic Disease Completed · 430 cited
  2. Phase 4 Roflumilast in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Fixed Dose Combinations of Long-acting β2-agonist (LABA) and Inhaled Corticosteroid (ICS) Completed · 125 cited
  3. Phase 4 The Study of the Use of Nintedanib in Slowing Lung Disease in Patients With Fibrotic or Non-Fibrotic Interstitial Lung Disease Related to COVID-19 Completed · 1 cited
  4. Phase 4 Treatment of Acute Sinusitis Completed
  5. Phase 3 Efficacy and Safety of Polyoxidonium, Nasal and Sublingual Spray, 6 mg/ml in Children Aged 1-12 Years With ARI Completed
  6. Phase 2 Evaluation of the Effect of AZD5069 in Patients With Bronchiectasis Completed
Show 22 more trials
  1. Phase 2 A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of GlaxoSmithkline (GSK) Biologicals' Investigational Vaccine GSK2838504A When Administered to Chronic Obstructive Pulmonary Disease (COPD) Patients With Persistent Airflow Obstruction. Completed
  2. Phase 2 Study to Assess the Immunogenicity and Safety of GSK's Investigational Vaccine (GSK3277511A) When Given to Healthy Smokers and Ex-smokers After Administration of Shingrix Vaccine Completed
  3. Phase 2 Vitamin D for Sickle-cell Respiratory Complications Completed
  4. Phase 2 A Study to Test if a Third Dose of the Vaccine is Safe in Current and Former Smokers Aged 40 to 80 Years Old and to Gather Information on the Immune Response Following the Third Dose of the Vaccine Completed
  5. Phase 2 A Study to Test if the Vaccine is Working Well in Chronic Obstructive Pulmonary Disease (COPD) Patients Aged 40 to 80 Years Old to Reduce Episodes of Worsening Symptoms and to Gather Further Information on Safety and Immune Response. Completed
  6. Phase 2 University of Wisconsin Meditation & Exercise Cold Study Completed
  7. Phase 2 Evaluating the Effect of Mucinex 1200mg on Mucociliary and Cough Clearance During an Acute Respiratory Infection Completed
  8. Phase 1 A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of the Investigational GSK Biologicals' GSK3277511A Vaccine in Adults. Completed
  9. Phase 1 A Long Term Follow-up Study up to 4 Years After Study Vaccination to Assess Immunogenicity and Safety of the Investigational Vaccine in Adults Completed
  10. Phase 1 Study to Evaluate the AIO-001 in Healthy Participants Completed
  11. N/A A Study to Assess Immunity to Specific Microbial Antigens in Healthy Smokers and Non-smokers and in Subjects With Stable COPD Completed
  12. N/A Infectious Pathogens in Acute Respiratory Illness in Adults and Elderly Completed
  13. N/A Utility of Continuous Pulse Oximetry for Pediatric Patients With Stable Respiratory Illness Completed
  14. N/A Prophylactic Efficacy of Relenza Against Influenza A and B Completed
  15. N/A Urgent Care Management of Respiratory Illness Enabled With Novel Testing Pathway Completed
  16. N/A Initial Specialist Telephone Consultation With New Patients in Secondary Care Completed
  17. N/A Comparing 6-Minute Walk Tests for Ambulatory Oxygen Assessment Completed
  18. N/A A Comparative Clinical Trial of the TensorTip, a Novel Non Invasive Device for Measurement Blood Parameters Completed
  19. N/A Engineering Evaluation of the Helix Ventilator Completed
  20. N/A Timing of Planned Caesarean Section and Morbidity of the Newborn Completed
  21. N/A Occurrence of Potential Bacterial and Viral Pathogens in Stable Chronic Obstructive Pulmonary Disease and During Acute Exacerbations of the Disease, in Asia Pacific Completed
  22. N/A FluSAFE: Flu SMS Alerts to Freeze Exposure Completed

Showing the 28 most-cited and recently-updated of 28 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Mid-turbinate swabs match nasopharyngeal swab sensitivity for any respiratory virus in children
Infectious Disease Meta-analysis
Mid-turbinate swabs match nasopharyngeal swab sensitivity for any respiratory virus in children Mid-turbinate swabs match the gold standard for catching kids respiratory viruses
This systematic review and meta-analysis evaluated diagnostic accuracy of nasopharyngeal aspirates, mid-turbinate swabs, anterior nasal swab…
Mid-turbinate swabs match the gold standard for catching kids respiratory viruses while being far more comfortable than the current method.
medRxiv Jun 3, 2026
Respiratory microbiome composition in children offers new ideas for precision treatment of respiratory diseases and asthma
Pulmonology & Critical Care Sys. Review
Respiratory microbiome composition in children offers new ideas for precision treatment of respiratory diseases and asthma New ideas for treating children with asthma and respiratory infections
This narrative review examines the respiratory microbiome, metabolites, and colonization in children with respiratory infections, allergic a…
This review offers fresh directions for understanding how the respiratory microbiome affects children with asthma and allergic airway inflam…
Frontiers May 29, 2026
Host factors influence viral entry and replication in HPIV infected infants, elderly, and immunocompromised individuals
Genetics & Precision Medicine Sys. Review
Host factors influence viral entry and replication in HPIV infected infants, elderly, and immunocompromised individuals Host factors influence how the parainfluenza virus infects vulnerable people
This narrative review discusses host factors influencing viral entry, replication, assembly, release, and innate immunity evasion in human p…
A review explains how host factors affect viral entry and immunity in infants, the elderly, and immunocompromised individuals with respirato…
Frontiers May 29, 2026
Systematic review maps 50 most-cited articles on pediatric respiratory infections
Pediatrics Sys. Review
Systematic review maps 50 most-cited articles on pediatric respiratory infections Most cited research on child respiratory infections comes from US, China, Canada
This systematic bibliometric review analyzed the 50 most-cited articles on pediatric respiratory infections. Key findings show a predominanc…
A review of 50 top-cited articles on pediatric respiratory infections shows most research comes from just three countries.
medRxiv May 22, 2026
Review synthesizes potential uses of Fritillariae Cirrhosae Bulbus alkaloids for various conditions
Drug Pipeline Sys. Review
Review synthesizes potential uses of Fritillariae Cirrhosae Bulbus alkaloids for various conditions Alkaloids from Fritillariae Cirrhosae Bulbus show promise for multiple health conditions
This narrative review evaluates the potential applications of alkaloids derived from Fritillariae Cirrhosae Bulbus. The authors synthesize e…
A review suggests alkaloids from Fritillariae Cirrhosae Bulbus may help with respiratory diseases, tumors, and hypertension, though more res…
Frontiers May 20, 2026
Narrative review evaluates Oxford Nanopore sequencing for pediatric infectious disease diagnostics
Infectious Disease Sys. Review
Narrative review evaluates Oxford Nanopore sequencing for pediatric infectious disease diagnostics New Pocket Device Finds Kids' Infections in Hours Not Days
This narrative review examines the use of Oxford Nanopore Technologies (ONT) sequencing in pediatric emergency infectious diseases. The auth…
• Real-time gene sequencing spots infections and antibiotic needs fast • Helps doctors treat seriously sick children in emergency rooms • St…
Frontiers May 8, 2026
Tai Chi reduces inflammatory gene expression in chronic disease patients
Oncology Meta-analysis
Tai Chi reduces inflammatory gene expression in chronic disease patients Tai Chi Calms Inflammation Genes in Chronic Disease Patients
A meta-analysis of 20 studies shows Tai Chi significantly downregulates pro-inflammatory genes like IL-6 and IL-1β in adults with chronic di…
A new review shows Tai Chi may quiet the body's inflammatory genes that drive chronic disease symptoms in adults.
Frontiers May 6, 2026
Perspective review discusses chronic air pollution effects on children and older adults in Puerto Rico
Primary Care & Family Medicine Sys. Review
Perspective review discusses chronic air pollution effects on children and older adults in Puerto Rico Air pollution may change your body’s microbes and raise cancer risk
This perspective review examines the impact of chronic air pollution and environmental exposures on children and older adults.
Tiny particles in the air we breathe may be altering the body’s microbiome and increasing cancer risk, especially in kids and older adults l…
Frontiers May 1, 2026
Effort Re-education Programme improves functionality in oncology patients with respiratory symptoms
Oncology RCT
Effort Re-education Programme improves functionality in oncology patients with respiratory symptoms Effort Re-education Programme improves function for oncology patients
In this stratified randomised clinical trial of 65 oncology patients, an Effort Re-education Programme (ERP) delivered after hospital discha…
A new breathing program may help oncology patients regain independence and reduce shortness of breath after leaving the hospital.
Apr 30, 2026
Systematic review links e-cigarette flavors to inflammation and cellular damage in animal models
Primary Care & Family Medicine Meta-analysis
Systematic review links e-cigarette flavors to inflammation and cellular damage in animal models E-cigarette flavors may increase nicotine use and health risks
This systematic review examines the health impacts of fruity, menthol/mint, and sweet e-cigarette flavors using animal models and human data…
Sweet, fruity, and minty e-cigarette flavors are linked to higher nicotine use and serious respiratory and cellular damage.
Frontiers Apr 30, 2026
Narrative review explores transcranial magnetic stimulation feasibility for chronic respiratory diseases
Physical Medicine & Rehab Sys. Review
Narrative review explores transcranial magnetic stimulation feasibility for chronic respiratory diseases New ideas for managing chronic respiratory diseases using brain stimulation
This narrative review evaluates the feasibility of transcranial magnetic stimulation as an adjunctive respiratory training approach for pati…
This review explores using transcranial magnetic stimulation to help patients with chronic respiratory disorders breathe easier and manage t…
Frontiers Apr 29, 2026
Cochrane review finds vitamin D may slightly reduce ARI healthcare visits in children
Gastroenterology Sys. Review
Cochrane review finds vitamin D may slightly reduce ARI healthcare visits in children Vitamin D may slightly cut cold visits for kids, but safety is key
This Cochrane systematic review of 31,521 participants found that vitamin D supplementation may slightly reduce the proportion of children w…
A large review of 31,521 people found vitamin D might slightly reduce cold visits for children, though it does not lower the average number …
Cochrane Apr 27, 2026

Questions about Respiratory Disease

Do cohort studies show clinical outcomes for pediatric acute respiratory infections?

Yes, cohort studies are the most common study type in pediatric ARI research, providing key data on pathogen profiles, co-infections, seasonal patterns, and clinical outcomes like hospitalization and severity.

Full answer →
How does chronic air pollution affect children and older adults in Puerto Rico?

Chronic air pollution in Puerto Rico increases risks of cancer, respiratory, and cardiovascular diseases, especially in children and older adults, through microbiome disruption and immune dysregulation.

Full answer →

All Respiratory Disease Articles