N/A
N=45
Transcranial Magnetic Stimulation (TMS) for Motor Symptoms in Psychiatric Disorders
Psychomotor Retardation · Psychomotor Slowing · Schizophrenia and Related Disorders · Major Depressive Disorder
Bottom Line
View on ClinicalTrials.gov: NCT03275766 ↗Enrolled (actual)
45
Serious AEs
2.3%
Results posted
May 2021
Primary outcome: Primary: Number of Responders at Week 3 — 4; 9; 0; 3 responders
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- DLPFC facilitatory (Other); SMA inhibitory (Other); SMA facilitatory (Other); sham TMS (Other)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Bern
- Primary completion
- Jul 2019
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Responders at Week 3 |
4; 9; 0; 3 | — |
| SECONDARY Change in Salpetriere Retardation Rating Scale Total Score From Baseline to Week 3 |
— | — |
| SECONDARY Change in Activity Level From Baseline to Week 3 |
— | — |
| SECONDARY Change in Catatonia Severity From Baseline to Week 3 |
— | — |
| SECONDARY Change in Fingertapping Score From Baseline to Week 3 |
— | — |
| SECONDARY Change in Coin Rotation From Baseline to Week 3 |
— | — |
| SECONDARY Change in Hand Gesture Performance From Baseline to Week 3 |
— | — |
| SECONDARY Change in SANS Total Score From Baseline to Week 3 |
— | — |
| SECONDARY Change From HAMD Total Score From Baseline to Week 3 |
— | — |
| SECONDARY Change in CAINS Total Score From Baseline to Week 3 |
— | — |
| SECONDARY Change in PANSS Total and Subscores From Baseline to Week 3 |
— | — |
Summary
Psychomotor slowing may occur in major psychiatric disorders, such as major depressive disorders or schizophrenia spectrum disorders. It refers to slowing of fine motor skills, motor planning and gross motor behavior. In major depression and schizophrenia, psychomotor slowing is associated with alterations of premotor cortex, dorsolateral prefrontal cortex and basal ganglia. This randomized, sham-controlled, prospective trial will test, whether 15 sessions of repetitive transcranial magnetic stimulation (rTMS) may ameliorate psychomotor slowing in schizophrenia or major depression.
Eligibility Criteria
Inclusion Criteria
- suffering from major depressive disorder or schizophrenia spectrum disorder according to DSM-5 criteria
- right handedness
- normal or corrected-to-normal vision and hearing
Exclusion Criteria
- epilepsy
- history of severe head trauma
- current abuse of drugs or alcohol; past addiction to drugs or alcohol
- pregnancy
- incompatibility to cerebral MRI
Data sourced from ClinicalTrials.gov (NCT03275766). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.