N/A
N=163
Simplified Isoniazid Preventive Therapy Strategy to Reduce TB Burden
Tuberculosis · HIV/AIDS
Bottom Line
View on ClinicalTrials.gov: NCT03315962 ↗Enrolled (actual)
163
Serious AEs
0.0%
Results posted
Jun 2025
Primary outcome: Primary: IPT Initiation Rate — 0.74; 0.65 events per person-years
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- SPIRIT Intervention (Behavioral)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of California, San Francisco
- Primary completion
- Nov 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY IPT Initiation Rate |
0.74; 0.65 | — |
Summary
The overall objective of this study is to determine if a multi-component implementation intervention (SPIRIT) and additional leadership and management training that targets District Health Officers (DHOs) can increase IPT initiation among HIV-infected persons, as compared to country standard practices, in a cluster randomized trial in Uganda.
Eligibility Criteria
AIM 1 - Spirit Intervention:
Inclusion Criteria
- District Health Officer or TB District Supervisor (or other DHO-appointed TB focal person) in Uganda.
- By definition, the DHO or TB District Supervisor are all ≥18 years of age.
Exclusion Criteria
- Planned departure from position as DHO or TB District Supervisor prior to randomization.
- DHOs from Kampala and Wakiso districts, Uganda.
Data sourced from ClinicalTrials.gov (NCT03315962). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.