N/A
N=105
Neurobiology of Alcohol and Nicotine Co-Addiction
Alcohol Use Disorder · Nicotine Use Disorder
Bottom Line
View on ClinicalTrials.gov: NCT03338933 ↗Enrolled (actual)
105
Serious AEs
0.0%
Results posted
Feb 2025
Primary outcome: Primary: Brain Activation During Functional Magnetic Resonance Imaging (fMRI) in Response to a Stress Modulated Cue Induced Craving Task (DSNBACK) — -26.1562; -45.2123; 18.4989; -8.8848 Percent signal change
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- magnetic resonance imaging (MRI) (Behavioral)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- VA Office of Research and Development
- Primary completion
- Jan 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Brain Activation During Functional Magnetic Resonance Imaging (fMRI) in Response to a Stress Modulated Cue Induced Craving Task (DSNBACK) |
-26.1562; -45.2123; 18.4989; -8.8848; -37.6450; -72.3998 | — |
| PRIMARY Brain Activation During Resting State MRI. |
0.1817; 0.1858; 0.1729; 0.1308; 0.1293; 0.1216 | — |
| PRIMARY Brain Cortical Thickness Assessed During MRI |
2.6111; 2.5421; 2.5472; 2.6560; 2.4885; 2.4414 | — |
| PRIMARY Brain White Matter Integrity as Assessed by Fractional Anisotropy During MRI |
0.4167; 0.3996; 0.4030; 0.4044; 0.3794; 0.3657 | — |
Summary
This proposal addresses the critical absence of information about the neurobiology of recovery from Alcohol Use Disorder (AUD) in alcohol and nicotine users.
Eligibility Criteria
Inclusion Criteria
- None
Exclusion Criteria
- None
Data sourced from ClinicalTrials.gov (NCT03338933). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.