N/A Completed N=105

Neurobiology of Alcohol and Nicotine Co-Addiction

Alcohol Use Disorder · Nicotine Use Disorder

Source: ClinicalTrials.gov NCT03338933 ↗

Enrolled (actual)

105

Serious AEs

0.0%

Results posted

Feb 2025

Primary outcomePrimary: Brain Activation During Functional Magnetic Resonance Imaging (fMRI) in Response to a Stress Modulated Cue Induced Craving Task (DSNBACK) — -26.1562; -45.2123; 18.4989; -8.8848 Percent signal change

Summary

This proposal addresses the critical absence of information about the neurobiology of recovery from Alcohol Use Disorder (AUD) in alcohol and nicotine users.

Outcome Measures

Outcome	Result	p-value
PRIMARY Brain Activation During Functional Magnetic Resonance Imaging (fMRI) in Response to a Stress Modulated Cue Induced Craving Task (DSNBACK)	-26.1562; -45.2123; 18.4989; -8.8848; -37.6450; -72.3998	—
PRIMARY Brain Activation During Resting State MRI.	0.1817; 0.1858; 0.1729; 0.1308; 0.1293; 0.1216	—
PRIMARY Brain Cortical Thickness Assessed During MRI	2.6111; 2.5421; 2.5472; 2.6560; 2.4885; 2.4414	—
PRIMARY Brain White Matter Integrity as Assessed by Fractional Anisotropy During MRI	0.4167; 0.3996; 0.4030; 0.4044; 0.3794; 0.3657	—

Eligibility Criteria

Inclusion Criteria

None

Exclusion Criteria

None

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03338933). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.