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N/A N=79 Randomized Supportive Care

Reducing Risk for Alzheimer's Disease in High-Risk Women Through Yogic Meditation Training

Mild Cognitive Impairment · Alzheimer's Disease

Bottom Line

View on ClinicalTrials.gov: NCT03503669 ↗
Enrolled (actual)
79
Serious AEs
0.0%
Results posted
Feb 2024
Primary outcome: Primary: Change in Hopkins Verbal Learning Test (HVLT) Total Recall Score — -0.94; -1.65 units on a scale — p=>0.05

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
Memory Training (Behavioral); Kundalini yoga and meditation (Behavioral)
Age
Adult, Older Adult · 50+ yrs
Sex
Female
Sponsor
University of California, Los Angeles
Primary completion
Jan 2021

Outcome Measures

OutcomeResultp-value
PRIMARY
Change in Hopkins Verbal Learning Test (HVLT) Total Recall Score		 -0.94; -1.65 >0.05
PRIMARY
Change in Delayed Recall Cognitive Domain Scores		 0.02; -0.31 0.008 sig
PRIMARY
Change in Executive Function Cognitive Domain Scores		 -0.03; -0.04 >0.05
SECONDARY
Change in Memory Functioning Questionnaire (MFQ) Scale		 0.29; 0.54; -0.30; 0.64; 0.51; 0.70 >0.05
SECONDARY
Change in Medical Outcomes Study Short Form 36-Item Health Survey (SF-36)		 0.60; 2.70; -15.90; 3.12; -18.18; 2.77 >0.05

Summary

The purpose of this pilot study will be to test whether Kundalini yoga (KY) and Kirtan Kriya (KK) yogic meditation is superior to Memory Enhancement Training (MET) for improving cognitive functioning, health (including cardiovascular factors), and mood in women with high AD risk.

Eligibility Criteria

Inclusion Criteria

  • Amnestic MCI, as defined by a Clinical Dementia Rating Scale score of .5.
  • High cardiovascular risk defined as at least one of the following:
  • 7.5 percentile risk or higher using ASCVD risk calculator
  • Myocardial Infarction more than 6 months ago
  • Diabetes
  • Taking medication for blood pressure > 140/90 blood pressure
  • Taking medication for lyperlipidemia LDL >160
  • Sufficient English proficiency and the 8th grade or higher reading level as determined by the word reading subtest of the Wide Range Achievement Test-IV (this criterion is necessary in order to ensure ability to participate in MET, which involves reading and writing and has a Flesch-Kinkaid school equivalency of 7th grade)
  • Capacity to provide informed consent

Exclusion Criteria

  • History of psychosis, bipolar disorder, alcohol/ drug dependence, or neurological disorder
  • Recent (within three months) surgery, anticipated surgery within next year, or unstable medical condition
  • Any disability preventing participation in MET or KK+KY (e.g., severe visual or hearing impairment)
  • Insufficient English proficiency to participate in either MET or KK+KY
  • Diagnosis of dementia
  • Mini Mental Health Examination score of 23 or below
  • Currently taking any psychoactive medication
  • Participation in a psychotherapy that involves cognitive training
  • Practice of Kundalini Yoga or Kirtan Kriya within the past year
  • Myocardial Infarction within the past 6 months
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03503669). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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