N/A
Completed N=31
Metabolic Effects of Sleep Extension in People With Obesity
Source: ClinicalTrials.gov NCT03594994 ↗Enrolled (actual)
31
Serious AEs
0.0%
Results posted
Dec 2025
Primary outcomePrimary: Insulin Sensitivity — -3.8; 0.9 µmol/kgFFM/min
Summary
This study is designed to determine the impact of extending sleep duration on glucose metabolism in people with obesity. Half of the participants will be instructed to increase their time-in-bed in order to achieve >7h sleep/night (sleep extension; n=15) while the other half will be be instructed to maintain their current sleep habits (n=15).
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Insulin Sensitivity |
-3.8; 0.9 | — |
| SECONDARY Hepatic Insulin Sensitivity Index |
0.4; -0.3 | — |
| SECONDARY Adipose Tissue Insulin Sensitivity Index |
2.4; -2.0 | — |
| SECONDARY Homeostatic Model Assessment of Insulin Resistance |
0.2; 0.3 | — |
| SECONDARY 24 Hour Glucose Area Under the Concentration Curve |
45; 41 | — |
| SECONDARY 24 Hour Insulin Area Under the Concentration Curve |
1; -44 | — |
| SECONDARY 24 Hour Non-esterified Fatty Acids Area Under the Concentration Curve |
1.0; -0.3 | — |
| SECONDARY Body Mass |
-1.1; -0.3 | — |
| SECONDARY Fat-free Mass |
-0.2; -0.5 | — |
| SECONDARY Body Fat |
0.5; 0.4 | — |
| SECONDARY Liver Fat |
-0.63; 0.6 | — |
| SECONDARY Fasting Glucose |
3.6; 0.8 | — |
| SECONDARY Daily Time in Bed |
0.3; 1.3 | — |
| SECONDARY Daily Total Sleep Time |
0.0; 1.1 | — |
| SECONDARY Stage N1 Sleep Time |
-1.3; 6.9 | — |
| SECONDARY Stage N2 Sleep Time |
-11.7; 23.9 | — |
| SECONDARY Stage N3 Sleep Time |
4.4; 14.9 | — |
| SECONDARY Rapid Eye Movement (REM) Sleep Time |
-1.6; 7.6 | — |
Eligibility Criteria
Inclusion Criteria
- Sleep 70 min/wk or moderate exercise >150 min/week
- Excessive alcohol consumption (>21 units of alcohol per week for men and >14 units of alcohol per week for women)
Data sourced from ClinicalTrials.gov (NCT03594994). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.