N/A
N=5
Pre-hospital ECMO in Advanced Resuscitation in Patients With Refractory Cardiac Arrest. ( SUB30 )
Death, Sudden, Cardiac · Out-Of-Hospital Cardiac Arrest · Ventricular Fibrillation · Cardiopulmonary Arrest With Successful Resuscitation
Bottom Line
View on ClinicalTrials.gov: NCT03700125 ↗Enrolled (actual)
5
Serious AEs
80.0%
Results posted
Aug 2025
Primary outcome: Primary: Proportion of Patients Successfully Established With Pre-hospital ECPR — 0 Participants
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- ECMO resuscitation (Procedure)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Barts & The London NHS Trust
- Primary completion
- Dec 2022
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Proportion of Patients Successfully Established With Pre-hospital ECPR |
— | — |
| SECONDARY Ambulance Dispatch |
— | — |
| SECONDARY Successful Cannulation |
2 | — |
| SECONDARY Number of Patients With Return of Spontaneous Circulations (ROSC) |
— | — |
| SECONDARY Emergency Call-out Time Frame |
16 | — |
| SECONDARY Successful Guide Wire Placement |
5 | — |
| SECONDARY Incidence of ECPR-related Complications |
1; 1; 1; 2 | — |
| SECONDARY Clinical Outcome Via FIM at 3 Months |
— | — |
| SECONDARY Clinical Outcome Via MRS at 3 Months |
0; 0; 0; 0; 1; 1 | — |
| SECONDARY Duration of Hospital Stay (ICU) |
16 | — |
| SECONDARY Number of Acute Hospital Admissions Post Discharge |
— | — |
Summary
To establish whether a pre-hospital advanced physician/ paramedic cardiac arrest team that is ECMO capable can establish ECMO flow within 30 minutes of collapse. The Sub30 study will investigate the technical and logistical feasibility of instituting pre-hospital Extracorporeal Cardiopulmonary Resuscitation (ECPR) within 30 minutes of collapse for selected patients (n=6) in a geographical sector of Greater London. It will achieve this through a unique collaboration between the primary emergency dispatch and response services (London Ambulance Service NHS Trust, LAS), pre-hospital practitioners (LAS and London Air Ambulance) and clinicians in ECMO (Barts Health NHS Trust).
Eligibility Criteria
Inclusion Criteria
Adult patients who:
- have a witnessed out-of-hospital cardiac arrest
- a presumed cardiac aetiology to their cardiac arrest
- receive bystander chest compressions within 3 minutes
- remain in cardiac arrest at 20 minutes following the call to the emergency services or fail to sustain ROSC in the pre-hospital setting
Exclusion Criteria
The following patients will not be suitable for entry into the study:
- Known to be are visibly appear younger than 18 years old or older than 65 years.
- Known or visible advanced pregnancy (when resuscitative hysterotomy should be performed)
- No signs of life (physical movement or breathing) AND evidence of ineffective chest compressions suggested by:
- absence of electrical activity at 20 minutes time out OR
- end tidal carbon dioxide level of less than 1.3 kPa (10 mmHg)
- Evidence from others present at the scene or patient examination that ECMO unlikely to benefit patient (e.g. advanced malignancy, severe frailty).
Data sourced from ClinicalTrials.gov (NCT03700125). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.