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Ventricular fibrillation

Part of Cardiac arrhythmias

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for ventricular fibrillation

17 trials tracked for ventricular fibrillation: 3 in phase 3 or 4.

17Trials tracked
3Phase 3 & 4
0Recruiting
0With published results
Phase distribution
Phase 4 3 Phase 1 1 Other / NA 13
  1. Phase 4 ADVANCE-D: Antitachycardia Pacing (ATP) Delivery for Painless Implantable Cardioverter Defibrillator (ICD) Therapy Completed
  2. Phase 4 The Use of Dual Chamber ICD With Special Programmed Features to Lower the Risk of Inappropriate Shock Completed
  3. Phase 4 ADVANCE CRT - D: Antitachycardia Pacing (ATP) Delivery for Painless Implantable Cardioverter Defibrillator (ICD) Therapy Completed
  4. Phase 1 Automatic External Defibrillation Monitoring in Cardiac Arrest Completed
  5. N/A Septal - Success Rate and Clinical Outcome of Septal Implant of Ventricular Defibrillation Lead Completed
  6. N/A Understanding Outcomes With the EMBLEM™ S-ICD in Primary Prevention Patients With Low Ejection Fraction Completed
Show 11 more trials
  1. N/A Acute Feasibility Investigation of a New S-ICD Electrode Completed
  2. N/A Shockless Implant Evaluation Completed
  3. N/A Evaluation of the iD-SystemTM, One-Handed Disposable Internal Defibrillation System. Completed
  4. N/A Electrophysiological Effects of Late PCI After MI Completed
  5. N/A DISCOVERY: Diagnostic Data and Genetic Polymorphisms in ICD Patients. Completed
  6. N/A DATAS: The Dual Chamber & Atrial Tachyarrhythmias Adverse Events Study Completed
  7. N/A Pre-hospital ECMO in Advanced Resuscitation in Patients With Refractory Cardiac Arrest. ( SUB30 ) Completed
  8. N/A Safety and Performance Study of the RELIANCE 4-Front Passive Fixation Lead Completed
  9. N/A CONNECT Study - Clinical Evaluation Of Remote NotificatioN to rEduCe Time to Clinical Decision Completed
  10. N/A SAFEty of Two Strategies of ICD Management at Implantation Completed
  11. N/A Vest Prevention of Early Sudden Death Trial and VEST Registry Completed

Showing the 17 most-cited and recently-updated of 17 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Cardiac arrhythmias

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Complete LVA ablation shows no arrhythmia-free survival benefit in persistent AF
Cardiology RCT
Complete LVA ablation shows no arrhythmia-free survival benefit in persistent AF Complete LVA Ablation Shows No Extra Benefit for AF
This post hoc subanalysis of an RCT compared complete low-voltage area (LVA) ablation versus no LVA ablation in 341 patients with persistent…
Adding complete low-voltage area ablation to standard AF treatment didn't improve outcomes in a new analysis.
Additional ablation after PVI improves AF freedom in non-diabetics but not in diabetics
Cardiology RCT
Additional ablation after PVI improves AF freedom in non-diabetics but not in diabetics Extra ablation may not help diabetes patients with atrial fibrillation
A subanalysis of an RCT in 493 patients undergoing catheter ablation for persistent AF found that adding linear and/or CFAE ablation to PVI …
For people with diabetes and atrial fibrillation, adding extra ablation beyond standard PVI may not lower recurrence risk.
Coexisting COPD and Atrial Fibrillation are associated with increased risk of mortality and bidirectional disease association
Cardiology Meta-analysis
Coexisting COPD and Atrial Fibrillation are associated with increased risk of mortality and bidirectional disease association Patients with both lung and heart conditions face higher risks
This meta-analysis of 48 publications identifies a significant bidirectional risk between Chronic Obstructive Pulmonary Disease (COPD) and A…
People living with both chronic lung disease and irregular heartbeats face significantly higher risks for mortality.
Evaluating the Efficacy of Oral Digoxin in Patients with Rheumatic Heart Disease
Cardiology RCT
Evaluating the Efficacy of Oral Digoxin in Patients with Rheumatic Heart Disease Trial shows digoxin reduces heart failure risk in rheumatic heart disease
A large multicenter trial shows oral digoxin significantly reduces the risk of heart failure and death in patients with rheumatic heart dise…
A large clinical trial suggests that the medication digoxin may lower the risk of worsening heart failure for patients with rheumatic heart …
SGLT2 inhibitors provide robust prognostic benefits in heart failure with inconsistent results in post-myocardial infarction settings
Cardiology Sys. Review
SGLT2 inhibitors provide robust prognostic benefits in heart failure with inconsistent results in post-myocardial infarction settings SGLT2 inhibitors show promise for heart failure and diabetes
This narrative review examines the cardiovascular and metabolic effects of SGLT2 inhibitors, specifically empagliflozin and dapagliflozin. T…
New evidence shows how SGLT2 inhibitors may protect the heart and manage risks for patients with type 2 diabetes and heart failure.
Incidental arrhythmia findings on ambulatory ECG vary widely in adults without prior atrial fibrillation
Cardiology Meta-analysis
Incidental arrhythmia findings on ambulatory ECG vary widely in adults without prior atrial fibrillation Hidden heart rhythm problems found in up to 96% of adults
This systematic review and meta-analysis of 136,344 community-based adults without prior atrial fibrillation found that the prevalence of in…
A review of 136,344 adults found hidden heart rhythm issues in up to 96% of people without known atrial fibrillation.
Renal denervation combined with pulmonary vein isolation increases freedom from atrial fibrillation risk in resistant hypertension patients
Cardiology Meta-analysis
Renal denervation combined with pulmonary vein isolation increases freedom from atrial fibrillation risk in resistant hypertension patients Renal denervation may help resistant hypertension patients with heart issues
This systematic review and meta-analysis evaluated renal denervation in patients with resistant hypertension. The pooled analysis included 8…
A meta-analysis suggests renal denervation improves heart and sleep markers in patients with resistant hypertension, though larger trials ar…
Hypertension history associates with 2.22-fold higher cognitive impairment risk in AF patients
Cardiology Meta-analysis
Hypertension history associates with 2.22-fold higher cognitive impairment risk in AF patients High blood pressure history doubles dementia risk in atrial fibrillation patients
This systematic review and meta-analysis of observational studies found that a history of hypertension is associated with an increased risk …
A history of high blood pressure is linked to a much higher risk of cognitive impairment in people with atrial fibrillation, according to a …
Left atrial appendage occlusion and NOACs reduce mortality compared with warfarin in atrial fibrillation
Cardiology Meta-analysis
Left atrial appendage occlusion and NOACs reduce mortality compared with warfarin in atrial fibrillation LAAO, low-dose NOACs beat warfarin for atrial fibrillation survival
A network meta-analysis compared left atrial appendage occlusion (LAAO), low-dose NOACs, standard-dose NOACs, and warfarin in non-valvular a…
For people with atrial fibrillation, warfarin may be the worst option for survival. New analysis finds LAAO and NOACs outperform it.
Pulsed-field ablation shows no significant AKI difference versus radiofrequency ablation in AF
Cardiology Meta-analysis
Pulsed-field ablation shows no significant AKI difference versus radiofrequency ablation in AF Pulsed-field ablation shows similar kidney risk as radiofrequency ablation
This systematic review and meta-analysis of 3,843 patients found no significant difference in acute kidney injury (AKI) between pulsed-field…
A large review found no major difference in kidney injury risk between two heart rhythm treatments, though one method showed slightly higher…
Discontinuing oral anticoagulation after AF ablation reduces bleeding without increasing thromboembolic risk
Cardiology Meta-analysis
Discontinuing oral anticoagulation after AF ablation reduces bleeding without increasing thromboembolic risk Stopping blood thinners after heart rhythm repair cuts bleeding risk without raising stroke danger
This systematic review and meta-analysis evaluated patients who stopped versus continued oral anticoagulation following atrial fibrillation …
A massive analysis shows stopping blood thinners after heart rhythm repair cuts bleeding risk without raising stroke danger for many patient…
Narrative review on atrial fibrillation and depression highlights bidirectional links and integrated care needs
Psychiatry Sys. Review
Narrative review on atrial fibrillation and depression highlights bidirectional links and integrated care needs Depression and heart rhythm problems may worsen each other
This narrative review synthesizes evidence on the bidirectional relationship between atrial fibrillation and depression. It suggests depress…
A new review suggests depression and atrial fibrillation can fuel each other, making it vital to screen for both conditions together.