N/A
Completed N=25
Theta Burst Stimulation in Young Adults With Depression
Source: ClinicalTrials.gov NCT03737032 ↗Enrolled (actual)
25
Serious AEs
0.0%
Results posted
Mar 2024
Primary outcomePrimary: Dorsomedial Prefrontal Cortex Activation — 0.16; 1.35; 0.36 score in arbitrary units — p=0.80
Summary
For the proposed 2-year study, the investigators will conduct a within-subject, counterbalanced investigation using functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS) to examine the acute effects of theta-burst stimulation (TBS) on function in dorsomedial prefrontal cortex (dmPFC) in 35 young adults with depression (18-25 years, 50% female).
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Dorsomedial Prefrontal Cortex Activation |
0.16; 1.35; 0.36 | 0.80 |
| SECONDARY Positive Affect |
20.70; 20.05; 20.45; 20.45; 19.80; 22.10 | 0.23 |
| SECONDARY VS-dmPFC Functional Connectivity |
2.28; 4.10; 1.16 | 0.84 |
Eligibility Criteria
Inclusion Criteria
- DSM-5 Diagnosis of Major Depressive Disorder, Persistent Depressive Disorder (Dysthymia), Other Specified Depressive Disorder, or Other Unspecified Depressive Disorder
Exclusion Criteria
- Bipolar disorder, substance dependence, or lifetime history of psychosis
- Neurological disorder (e.g., seizure disorder)
- Pregnant
- MRI contradictions: claustrophobia, permanent orthodontic devices, metal implants or other forms of metal in the body that cannot be removed
Data sourced from ClinicalTrials.gov (NCT03737032). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.