Phase 2 Completed N=48 Randomized Treatment

Post-Stroke Optimization of Walking Using Explosive Resistance

Source: ClinicalTrials.gov NCT03826771 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Apr 2025

Primary outcomePrimary: Change in Mean Score of Depression as Assessed by the Hamilton Rating Scale for Depression — 5.20; 2.17; 0.14 units on a scale

Summary

The investigators will study the effects of a 12 week strength training program on individuals who have had a stroke and are depressed to see if this type of exercise training helps treat depression and improves walking function. Our goal is to use the information collected in this study to help design treatments for people who have had a stroke that will help with many of the common consequences of stroke, including depression, muscle weakness and slow walking. Progress toward overcoming some of these issues would be incredibly valuable to any person who has had a stroke and their families.

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in Mean Score of Depression as Assessed by the Hamilton Rating Scale for Depression	5.20; 2.17; 0.14	—
SECONDARY Change in Self Selected Walking Speed	0.08; 0.06; 0.21	—

Eligibility Criteria

Inclusion Criteria

age 50-70
stroke within the past 6 to 60 months
residual paresis in the lower extremity (Fugl-Meyer LE motor score 200 mmHg and diastolic >110 mmHg at rest
attempt of suicide in the last 2 years or at suicidal risk assessed by SCID interview
History of seizures or currently prescribed anti-seizure medications
Current enrollment in a clinical trial to enhance motor recovery
Pregnancy

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03826771). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.