Phase 2
N=48
Post-Stroke Optimization of Walking Using Explosive Resistance
Stroke · Depression
Bottom Line
View on ClinicalTrials.gov: NCT03826771 ↗Enrolled (actual)
48
Serious AEs
0.0%
Results posted
Apr 2025
Primary outcome: Primary: Change in Mean Score of Depression as Assessed by the Hamilton Rating Scale for Depression — 5.20; 2.17; 0.14 units on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 2
- Interventions
- Power training (Behavioral); Stretching (Behavioral)
- Age
- Adult, Older Adult · 50+ yrs
- Sex
- All
- Sponsor
- Medical University of South Carolina
- Primary completion
- Mar 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Mean Score of Depression as Assessed by the Hamilton Rating Scale for Depression |
5.20; 2.17; 0.14 | — |
| SECONDARY Change in Self Selected Walking Speed |
0.08; 0.06; 0.21 | — |
Summary
The investigators will study the effects of a 12 week strength training program on individuals who have had a stroke and are depressed to see if this type of exercise training helps treat depression and improves walking function. Our goal is to use the information collected in this study to help design treatments for people who have had a stroke that will help with many of the common consequences of stroke, including depression, muscle weakness and slow walking. Progress toward overcoming some of these issues would be incredibly valuable to any person who has had a stroke and their families.
Eligibility Criteria
Inclusion Criteria
- age 50-70
- stroke within the past 6 to 60 months
- residual paresis in the lower extremity (Fugl-Meyer LE motor score 200 mmHg and diastolic >110 mmHg at rest
- attempt of suicide in the last 2 years or at suicidal risk assessed by SCID interview
- History of seizures or currently prescribed anti-seizure medications
- Current enrollment in a clinical trial to enhance motor recovery
- Pregnancy
Data sourced from ClinicalTrials.gov (NCT03826771). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.