N/A
N=67
Translational Development of Photon-counting CT Imaging
Cancer · Inflammatory Disease · Vascular Diseases · Metabolic Bone Disease
Bottom Line
View on ClinicalTrials.gov: NCT03878134 ↗Enrolled (actual)
67
Serious AEs
0.0%
Results posted
Sep 2023
Primary outcome: Primary: Mean Difference in Diagnostic Image Quality Grading of Photon Counting CT vs Conventional CT Images. — 0.947368421 score on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- PHOTON COUNTING CT Scanner (Device)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- National Institutes of Health Clinical Center (CC)
- Primary completion
- Jan 2022
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Mean Difference in Diagnostic Image Quality Grading of Photon Counting CT vs Conventional CT Images. |
0.947368421 | — |
Summary
Using an investigational CT scanner which uses a new type of detector to capture X-rays, (a photon counting CT detector), the goal of this experimental study is to compare conventional CT images to CT images using the photon counting detector in patients undergoing CT scans for clinically indicated reasons. The main question it aims to answer is whether the images produced using the new detectors are superior in quality. Participants will undergo the clinically indicated CT images and the photon counting detector CT images of a limited area during the same examination time.
Eligibility Criteria
- INCLUSION CRITERIA:
- NIH patients currently on an NIH research protocol who are referred to RAD&IS for CT examination as part of that research protocol
- 18 years old or greater
- Able to understand and sign informed consent
EXCLUSION CRITERIA
- Studies that specifically require simultaneous dual source CT scan capability or where dual source CT scan is requested
- Studies ordered for an emergency indication
- Pregnant women. Subjects of child-bearing potential will undergo serum or urine pregnancy testing within 72 hours before examination. Post-menopausal and surgically sterilized subjects are automatically exempt from this testing
- Lactating women who are unable to stop breast feeding for 24 hours following the administration of contrast
- Body weight >500 lbs (227 kg) or a body circumference that prevents the study subject from lying flat in the scanner
- Patients who have undergone PCCT examination within the past year.
- Any contraindications that the research team identifies from the subject, RAD&IS CT questionnaires, and/or History and Assessment
- Employees or staff supervised by the Principal Investigator or an Associate will not be recruited to participate
Data sourced from ClinicalTrials.gov (NCT03878134). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.