Acidic microenvironments reprogram immune cells via pH sensors, driving tissue injury
Acidic environments in the body change how immune cells work
This systematic review synthesizes evidence that acidic microenvironments influence immune cell metabolism and effector functions through pr…
Your immune system uses special sensors to detect acid levels, which can trigger inflammation and tissue damage during infections or cancer.
Transcutaneous Vagus Nerve Stimulation utilizes distinct auricular and cervical pathways for non-invasive treatment applications
Two different ways to stimulate the vagus nerve for treatment
This narrative review examines the anatomical access points and methodologies for transcutaneous Vagus Nerve Stimulation (tVNS). It distingu…
New research highlights two distinct paths for non-invasive nerve stimulation to treat conditions like migraine and depression.
Narrative review discusses paradoxical inflammatory reactions in pediatric patients receiving biologic therapy
Biologic therapy may cause paradoxical inflammation in children
This narrative review examines paradoxical inflammatory reactions in pediatric patients receiving biologic therapy. The authors note that a …
A review notes that biologic therapy can trigger paradoxical inflammatory reactions in pediatric patients, highlighting a need for careful m…
Molecular review explores Siglec signaling pathways in cancer and inflammatory disorders
Siglec proteins help immune system balance fighting disease and avoiding self-harm
This molecular review examines the role of Siglec signaling pathways in human biology. The authors discuss potential therapeutic opportuniti…
Siglec proteins act as brakes on immune cells, and targeting them could help treat cancer and autoimmune disorders.
Narrative review outlines sialidase biology roadmap for genetic syndromes and inflammatory disorders
Sialidase Clues Solve Mystery Diseases Doctors Couldn't Explain
This narrative review examines sialidase biology across genetic syndromes, infectious pathogens, inflammatory disorders, autoimmune disorder…
• Sialidase imbalance links rare genetic disorders to common diseases like cancer • Patients with mysterious symptoms getting wrong treatmen…
Narrative review advocates multi-omics models to clarify exercise associations
Exercise links to health benefits, but direct causation remains associative
This narrative review discusses the complex relationship between exercise and health outcomes.
A narrative review suggests exercise connects to health outcomes, though direct causation remains associative and knowledge gaps persist.
Integrative review of Tedania sponge compounds for cancer and infections
Sponge Compounds May Fight Cancer and Infections, Study Suggests
This integrative review synthesizes evidence on 135 compounds from Tedania marine sponges for cancer, inflammatory diseases, and microbial i…
Marine sponges are a rich source of natural compounds that could one day lead to new treatments for cancer and infections, but more research…
Retrospective FAERS analysis reveals sex-specific adverse event patterns for apremilast, crisaborole, and roflumilast in chronic inflammatory diseases
Why Side Effects Hit Men and Women Differently
This retrospective pharmacovigilance study analyzed 127,516 apremilast reports, 7,562 crisaborole reports, and 2,142 roflumilast reports wit…
A massive new analysis reveals that common anti-inflammatory drugs cause different side effects in men and women, meaning biology is more co…
Review of ISG15 pathway targeting for inflammatory and cardiovascular diseases
A Tiny Protein That Fuels Your Inflammation
This narrative review examines the potential of targeting the ISG15 pathway to treat inflammatory diseases, including skin, cardiovascular, …
Understanding this protein could lead to better medicines for skin, heart, and brain diseases.
Questions about inflammatory diseases
Does targeting ISG15 help with skin inflammatory diseases?
Targeting the ISG15 pathway shows potential for treating skin inflammatory diseases because ISG15 can act as a cytokine that worsens inflammation, but current research is mostly theoretical.
Full answer →Can marine sponge compounds treat infections and inflammatory diseases?
Marine sponge compounds show promise for treating infections and inflammatory diseases, with specific examples like manzamines for malaria and diketopiperazines for sepsis.
Full answer →