N/A
Completed N=105
Preventing Opioid Overdose Mortality in the United States
Source: ClinicalTrials.gov NCT03924505 ↗Enrolled (actual)
105
Serious AEs
0.0%
Results posted
Dec 2024
Primary outcomePrimary: Naloxone Coverage (Consistency) — 0.9; 0.4 proportion of participants — p=<0.01
Summary
This study aims to conduct a randomized controlled trial of 105 syringe services programs (SSPs) throughout the United States to understand the effectiveness of a multifaceted, facilitation-based strategy at advancing naloxone implementation effectiveness within SSPs. Together, these efforts can improve access to naloxone for people at high risk of overdose, thereby improving our nation's response to the opioid overdose epidemic.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Naloxone Coverage (Consistency) |
0.9; 0.4 | <0.01 sig |
| PRIMARY Naloxone Doses Distributed (Consistency) |
2.5; 1.3 | 0.01 sig |
| PRIMARY Best Practice Adoption (Implementation Quality) |
13.1; 12.9 | 0.68 |
Eligibility Criteria
To be eligible, an organization must have: 1) met the definition of an SSP - an organization whose primary function is to distribute drug use supplies to participants to reduce harms associated with drug use, 2) implemented OEND for a minimum of 6 months, and 3) completed the national survey of syringe services programs fielded February-July 2019. We excluded organizations such as fire departments or emergency departments of hospitals that offered supply distribution since it would be an ancillary function of these organizations and OEND programs that were not part of a syringe services program.
Data sourced from ClinicalTrials.gov (NCT03924505). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.