Report estimates state-level economic costs of opioid use disorder and fatal overdose
Report estimates state-level economic costs of opioid use disorder and overdose
A report estimated state-level economic costs of opioid use disorder and fatal opioid overdose in the United States.
A new report estimates the economic costs of opioid use disorder and fatal overdoses for every state in the United States in 2017.
Naloxone prescriptions from US retail pharmacies increased substantially from 2012 to 2018
Did naloxone access improve? Pharmacy prescriptions more than doubled in one year
An observational report of naloxone dispensing trends in US retail pharmacies found the number of prescriptions increased substantially from…
Naloxone prescriptions at U.S. retail pharmacies more than doubled from 2017 to 2018, showing a major jump in access to this life-saving ove…
Report describes overdose education and naloxone distribution programs in U.S. syringe service programs
How do syringe programs teach people to stop overdoses?
A report describes overdose education and naloxone distribution (OEND) programs within syringe service programs in the United States.
A new report looks at how syringe service programs across the U.S.
Analysis examines synthetic opioid and stimulant co-involved overdose deaths by occupations and industries
Analysis looks at overdose deaths involving both opioids and stimulants across different jobs
An observational report analyzed synthetic opioid and stimulant co-involved overdose deaths across occupations and industries in the United …
A new analysis examines how different jobs and industries might connect to overdose deaths involving both synthetic opioids and stimulants.
Pennsylvania report examines controlled substance prescribing patterns before fatal overdoses
What prescriptions did people have before dying from an overdose in Pennsylvania?
An observational report from Pennsylvania analyzed controlled substance prescribing patterns preceding fatal overdoses involving opioids, st…
A new Pennsylvania report maps the controlled substance prescriptions people received before dying from an overdose involving opioids or sti…
Nitazene-related deaths reported in Tennessee field notes
Health officials report nitazene-related overdose deaths in Tennessee
Field notes from Tennessee report nitazene-related deaths. The study type, population, and specific results were not reported. Clinicians sh…
Tennessee health officials warn that nitazenes, powerful synthetic opioids sometimes mixed with other drugs, are linked to recent overdose d…
Case series identifies 38 medetomidine-involved opioid overdoses in Chicago
Chicago health officials identify overdoses involving veterinary sedative mixed with opioids
A case series in Chicago identified 38 individuals with medetomidine-involved opioid overdoses (12 confirmed, 26 probable).
Chicago officials warn that a veterinary sedative is now mixed with opioids in street drugs, causing 38 overdoses in the city.
Lifetime opioid overdose reported by 55% of pregnant individuals with OUD in buprenorphine treatment study
What puts pregnant women with opioid addiction at highest risk for overdose?
A descriptive analysis of baseline data from a multisite RCT of 140 pregnant individuals with OUD receiving buprenorphine found 55% reported…
Pregnant women in opioid treatment face high overdose risk if they have used heroin, experienced trauma, or rely on others for money.
Research across Opioid Use Disorder
Related studies from across the Opioid Use Disorder family.
Identifying Barriers to Mental Health Treatment in Collaborative Care for Opioid Use Disorder
Identifying Barriers to Mental Health Care for Patients with Opioid Use Disorder
A secondary analysis of a collaborative care model reveals significant barriers to counseling and medication for patients with co-occurring …
New data shows that certain factors like stimulant use and lower education can make it harder for patients to get mental health help.
Collaborative care improves depression severity in low-complexity patients with OUD and depression
Collaborative care helps some patients with opioid use and depression
This secondary analysis of a randomized clinical trial involving 797 adults with OUD, depression, and/or PTSD found that collaborative care …
Collaborative care may improve depression symptoms for some patients with opioid use disorder, depending on the complexity of their mental h…
AI and machine learning tools show potential for screening and managing substance use disorders
Artificial intelligence shows promise in managing substance use disorders
This narrative review explores the role of artificial intelligence and machine learning in managing alcohol, opioid, and cannabis use disord…
New data shows that artificial intelligence tools can help reduce hospital readmissions and relapse risks for people struggling with alcohol…
Proposed network meta-analysis aims to establish evidence hierarchy for non-pharmacological opioid use disorder interventions
Comparing Non-Pharmacological Treatments for People with Opioid Use Disorder
This is a protocol for a systematic review and network meta-analysis regarding non-pharmacological interventions for opioid use disorder. Th…
Doctors are planning a large study to see if non-drug therapies can work as well as methadone or buprenorphine for patients.
Stimulant use is associated with increased social needs and severity in patients with opioid use disorder
Stimulant use linked to harder road for opioid treatment
This cross-sectional study examined the relationship between stimulant use and clinical outcomes in patients with opioid use disorder and co…
Patients using cocaine or methamphetamine face more severe symptoms and fewer treatment resources for opioid use and mental health issues.
No genetic loci reached genome-wide significance for inpatient opioid exposure after joint arthroplasty
Genetic Research Looks at Opioid Use After Joint Replacement Surgery
This meta-analysis of a genome-wide association study (GWAS) analyzed 27,896 patients undergoing knee or hip arthroplasty to identify geneti…
Researchers analyzed the genetic data of over 27,000 patients to see if specific genes predict how much opioid medication a person needs aft…
Methadone shows significantly higher treatment retention than buprenorphine-naloxone in patients with Opioid Use Disorder
Methadone beats buprenorphine for opioid treatment retention
This meta-analysis of 7 randomized controlled trials involving 3622 patients found that methadone is associated with significantly higher tr…
Methadone keeps more people in opioid treatment than buprenorphine-naloxone, but the combo drug has fewer serious side effects.
Opioid Wizard tool increases primary care clinician confidence in screening, diagnosing, and referring patients for OUD
Digital Tool Improves Clinician Confidence in Managing Opioid Use Disorder
This secondary analysis of an RCT evaluates the Opioid Wizard clinical decision support tool's impact on primary care clinicians managing op…
A new digital decision support tool helps primary care doctors feel more confident when screening and diagnosing patients with opioid use di…
19 genome-wide significant loci identify genetic architecture and high correlations with other substance use disorders
Genes linked to stimulant addiction found in largest study yet
This meta-analysis of 709,369 individuals identifies 19 genome-wide significant loci associated with Stimulant Use Disorder. The study also …
Scientists found 19 genetic regions tied to stimulant addiction, including one linked to obesity. The study of over 700,000 people also show…
High-dose buprenorphine induction protocol for Opioid Use Disorder in emergency department settings
New plan to test high-dose buprenorphine for opioid use disorder
This randomized clinical trial protocol describes a plan to evaluate high-dose buprenorphine induction for patients with moderate-to-severe …
A new clinical trial plans to see if higher doses of buprenorphine can help more people with opioid use disorder start treatment in the emer…
Intranasal naloxone reverses opioid-induced respiratory depression in opioid-naive and daily users within 2 to 17 minutes
Narcan nasal spray reverses opioid breathing depression quickly
This prospective crossover trial enrolled 12 opioid-naive individuals and 18 daily opioid users.
Narcan nasal spray restored breathing within minutes in opioid users, but some had delayed or incomplete recovery.
Nicotinic partial agonists show no effect on opioid use in HIV-positive smokers
New data on nicotine treatment for HIV patients who use opioids
This secondary analysis of a randomized trial in 97 HIV-positive smokers with risky alcohol use and baseline opioid use found no significant…
A new look at nicotine treatment for HIV patients who use opioids found no difference in opioid use between two drug groups.