N/A N=76 Evaluation of a Computerized Opioid Overdose Prevention Program
Computer + Fluency · Computer Only · Treatment as Usual
Primary: Knowledge Gain — 30.6; 30.5; 27.56; 40.7 units on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=319 Increasing Naloxone Access for Persons Who Use Opioids
Naloxone
Primary: The Number of Participants That Completed the Training in 6 Months — 55; 56; 10; 9 Participants
Phase 4 N=256 Project OOPEN: Opioid Overdose Prevention, Education and Intervention
Opioid Overdose
Primary: Rate of Fatal Opioid Overdose — 2; 6 Participants
N/A N=190 Opioid Prescribing After Cesarean Delivery
Surgery · Opioid Use
Primary: Unused Opioids — 5; 10 oxycodone 5mg tablets
N/A N=204 Safety & Prevention Outcomes Study
Drug Overdose · Opioid-Related Disorders
Primary: Overdose Risk Behavior — -1.54; -0.51 Scores on a scale
N/A N=395 Naloxone Auto-injector as a Universal Precaution for Patients With Opioid Use Disorder
Opiate Antagonist Overdose · Opioid-Related Disorders
Primary: To Measure the Association of Take-home Naloxone With Overdose Reversals Performed by Patients With Opioid Use Disorder Enrolled in an Opioid Treatment Program — 73; 263…
N/A N=299 Primary Care Intervention to Reduce Prescription Opioid Overdoses
Pain · Drug Overdose · Opioid Use Disorders
Primary: Overdose Risk Behaviors — 1.31; 1.21; 1.45; 1.25 score on a scale
N/A N=105 Preventing Opioid Overdose Mortality in the United States
Opioid Overdose
Primary: Naloxone Coverage (Consistency) — 0.9; 0.4 proportion of participants — p=<0.01
N/A N=43 Preventing Overdose Using Information and Data From the Environment
Opioid Overdose · Drug Overdose
Primary: Cumulative Incidence of Accidental Fatal and Non-Fatal Drug Overdoses — 43.5; 37.1 Overdoses per 10,000 residents
N/A N=196 Discharge Opioid Education to Decrease Opioid Use After Cesarean
Opioid Use
Primary: Opioid Use — 7.5; 10 hydrocodone tablets
N/A N=49 Prevention of Opioid-Induced Hypoxemia
Non-cardiac Surgery
Primary: Time-weighted Average of SpO2 Below a Threshold of 90% — 0.29; 0.11; 0.16; 0.10 % of SpO2 — p=0.120
N/A N=29 Signs and Symptoms of Opioid-associated Iatrogenic Withdrawal in Critically Ill Adults
Substance Withdrawal Syndrome
Primary: Description of Signs and Symptoms of OIWS in Patients Who Scored Positive for Withdrawal Syndrome (OIWS) According to Diagnostic and Statistical Manual of Mental…
Phase 3 N=199 Naloxone for Optimizing Hypoxemia Of Lung Donors
Brain Death · Organ Donors · Lung Transplantation
Primary: Change in Oxygenation (P/F Ratio) From Baseline to Final Pre-recovery Arterial Blood Gas (ABG) — 81; 80 mm Hg
Phase 3 N=10 Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age
Opioid Toxicity · Pupillary Miosis · Respiratory Depression
Primary: Area Under the Time Concentration Curve (AUROC ) — 0.9700 Probability
N/A N=97 User Acceptability of a Device-Based Opioid Overdose Intervention
Opioid Overdose · Opioid-use Disorder · Substance Use Disorders
Primary: Community Need for a Device-based Opioid Overdose Intervention — 69; 22 Participants
N/A N=115 Suicide Prediction and Prevention for People at Risk for Opioid Use Disorder: Supplement to COMPUTE 2.0
Opioid Use · Opioid-use Disorder · Suicide
Primary: Number of Participants With CSSRS Completion on the Same Day or in the 14 Days Following Any Outpatient Visit — 14; 8 Participants
N/A N=268 Repeated-dose Behavioral Intervention to Reduce Opioid Overdose
Opioid-Related Disorders · Drug Overdose
Primary: Number of Overdose Events — 0; 0 overdoses
N/A N=115 Opioid Treatment and Recovery Through a Safe Pain Management Program
Depression · Opioid Use · Chronic Pain
Primary: Odds of Morphine Equivalent Daily Dose (MEDD) of Opioid Prescription >=50 mg — 0.209; 0.417; 0.185; 0.364 odds of prescription high dose — p=0.956
N/A N=321 Subthreshold Opioid Use Disorder Prevention (STOP) Trial
Opioid-use Disorder
Primary: Days of Risky Opioid Use in Past 180 Days — 12.2; 15.5 days
N/A N=52 Effect of Opioids on Ventilation in Children With Obstructive Sleep Apnea
Respiratory Depression · Obstructive Sleep Apnea
Primary: Respiratory Depression Following Opioids — -38.1; -37.1 percentage of change from baseline
Phase 2 N=14 Non-intrusive Detection of Temporary Neurologic Impairment By Opioids
Healthy
Primary: Oculo-Cognitive Addition Test (OCAT) Completion Time — 57.22; 57.22; 59.56; 58.18 seconds
N/A N=41 Buprenorphine Treatment Engagement and Overdose Prevention
Opioid-use Disorder
Primary: Buprenorphine Treatment Adherence — 19.7; 16.1 percentage of urine samples — p=0.914
N/A N=127 Post-op Crowd Sourcing Health Data Via Text-messaging
Orthopedic Surgery · Opioid Use · Acute Injuries Knee
Primary: Number of Opioid Tablets Taken Within 28 Days — 8.05; 11.55 number of pills taken
N/A N=150 Peer Intervention to Link Overdose Survivors to Treatment (PILOT)
Opioid Overdose
Primary: Number of Self-reported Overdose Risk Behaviors at 180 Days (6 Months) After Index ED Admission — 4.5; 5.6 units on a scale — p=0.399
N/A N=155 Technology for MAT in Primary Care - Phase 2
Opioid-use Disorder
Primary: Urine Drug Screening Test Results — 92.3; 92.0; 1.9; 2.0 percentage of participants positive
Phase 2 N=120 Ambulatory Gynecologic Surgery: Finding the Optimal Opioid Prescription
Surgery
Primary: Number of Oxycodone Tablets Used Day 1 — 1.0; 1.0 Oxycodone Tablets — p=.87
N/A N=93 Reduced Opioid Analgesic Requirements Via Improved Endogenous Opioid Function
Chronic Pain
Primary: Mean of the Change in Morphine Dosage (in mg) Required to Achieve 25% Reduction in Thermal Evoked Pain Responses Relative to Baseline (Pre-intervention) Placebo…
N/A N=80 A Tailored, Peer-delivered Intervention to Reduce Recurring Opioid Overdoses
Drug Overdose · Opioid-Related Disorders · Drug Addiction
Primary: Medication-Assisted Treatment Enrollment — 7; 13 Participants
N/A N=81 SafetyNet Program for Opioid Use Disorder (OUD)
Opioid-Use Disorder (OUD)
Primary: Frequency of Positive Urine Tests at 30 Days (Chart Review) — 35; 45; 1; 0 Participants
N/A N=30 Resilience Training for First Responders in the Opioid Epidemic
Compassion Fatigue · Burnout · Stress
Primary: Five Factor Mindfulness Questionnaire (FFMQ) — 111.6 score on a scale