Phase 3
Completed N=60
A Study of the Effectiveness of Venetoclax in Combination With Azacitidine or Decitabine in an Outpatient Setting in Patients With Acute Myeloid Leukemia (AML) Ineligible for Intensive Chemotherapy
Acute Myeloid Leukemia (AML) · Cancer
Source: ClinicalTrials.gov NCT03941964 ↗
Enrolled (actual)
60
Serious AEs
68.3%
Results posted
Mar 2023
Primary outcomePrimary: Percentage of Participants With Complete Remission or Complete Remission With Incomplete Blood Count Recovery (CR + CRi) — 70.0; 63.3 percentage of participants
◆ Published Evidence
Emerging
10citations · ~5 / year
A phase 3b study of venetoclax and azacitidine or decitabine in an outpatient setting in patients with acute myeloid leukemia.
Summary
A study evaluating the effectiveness and safety of venetoclax, in combination with azacitidine or decitabine, in an outpatient setting for treatment-naïve participants with AML who are ineligible for intensive chemotherapy.
Linked Publications
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A phase 3b study of venetoclax and azacitidine or decitabine in an outpatient setting in patients with acute myeloid leukemia.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Percentage of Participants With Complete Remission or Complete Remission With Incomplete Blood Count Recovery (CR + CRi) |
70.0; 63.3 | — |
| SECONDARY Percentage of Participants With Complete Remission (CR) |
13.3; 26.7 | — |
| SECONDARY Percentage of Participants With Complete Remission With Incomplete Blood Count Recovery (CRi) |
56.7; 36.7 | — |
| SECONDARY Percentage of Participants With Post-baseline Transfusion Independence |
50.0; 60.0; 73.3; 73.3; 50.0; 60.0 | — |
Eligibility Criteria
Inclusion Criteria
- Participant has confirmation of acute myeloid leukemia (AML) by World Health Organization (WHO) criteria
- Participant is deemed by the investigator to be an appropriate candidate for outpatient ramp-up of venetoclax
- Participant is not eligible to receive treatment with standard cytarabine and anthracycline induction regimens
- Participant has not received prior treatment for AML (treatment naïve) with the exception of hydroxyurea
- Participant has no evidence of spontaneous tumor lysis syndrome (TLS) at Screening
- Participant can have progressed from myelodysplastic syndrome (MDS) or be considered to have secondary AML and could have been treated with growth factors or other agents with the exception of hypomethylating agents
- Participant has adequate kidney, liver, and hematology laboratory values as detailed in the protocol
- Has an Eastern Cooperative Oncology Group (ECOG) Performance status of 0 to 3
Exclusion Criteria
Has a history of the following conditions:
- Acute promyelocytic leukemia
- Known active central nervous system involvement with AML
- Positive for HIV (HIV testing is not required)
- Positive for hepatitis B or C infection with the exception of those with an undetectable viral load within 3 months
- Cardiovascular disability status of New York Heart Association Class > 2
- Chronic respiratory disease that requires continuous oxygen or any other medical condition that in the opinion of the investigator would adversely affect his/her participating in this study
- Malabsorption syndrome or other condition that precludes enteral route of administration
Has a history of other malignancies within 2 years prior to study entry, with the exception of:
- Adequately treated in situ carcinoma of the cervix uteri or carcinoma in situ of breast
- Basal cell carcinoma of the skin or localized squamous cell carcinoma of the skin
- Previous malignancy confined and surgically resected (or treated with other modalities) with curative intent
Data sourced from ClinicalTrials.gov (NCT03941964) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.