N/A
N=243
Comparing Group Therapies for Veterans With Depression and PTSD
Major Depressive Disorder · Posttraumatic Stress Disorder
Bottom Line
View on ClinicalTrials.gov: NCT03979040 ↗Enrolled (actual)
243
Serious AEs
0.0%
Results posted
Jul 2024
Primary outcome: Primary: Depression Anxiety Stress Scale (DASS-Depression) — 10.6; 11.0; 8.8; 8.1 units on a scale — p=.025
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Group Transdiagnostic Behavior Therapy (Behavioral); Group Disorder-Specific Therapy (G-DSTs) (Behavioral)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- VA Office of Research and Development
- Primary completion
- Jun 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Depression Anxiety Stress Scale (DASS-Depression) |
10.6; 11.0; 8.8; 8.1; 8.5; 9.9 | .025 sig |
| PRIMARY Illness Intrusiveness Ratings Scale (IIRS) |
62.6; 59.3; 59.0; 52; 53.8; 52.9 | .025 sig |
| PRIMARY PTSD Checklist for DSM-5 (PCL-5) |
43.4; 40.0; 40.3; 33.9; 36.9; 35.9 | .025 sig |
Summary
Cognitive behavioral therapy (CBT) is a brief, efficient, and effective psychotherapy for individuals with depressive and PTSD. However, CBT is largely underutilized within Veteran Affairs Medical Centers (VAMCs) due to the cost and burden of trainings necessary to deliver the large number of CBT protocols. Transdiagnostic Behavior Therapy (TBT), in contrast, is specifically designed to address numerous distinct disorders within a single protocol. The transdiagnostic approach of TBT has the potential to dramatically improve the accessibility of CBT within VAMCs and therefore improve clinical outcomes of Veterans. The proposed research seeks to evaluate the efficacy of a group version of TBT (G-TBT) by assessing clinical outcomes and quality of life in VAMC patients with major depressive disorder and PTSD throughout the course of treatment and in comparison to two existing group disorder-specific therapies (G-DST), CBT for Depression and Cognitive Processing Therapy for PTSD.
Eligibility Criteria
Inclusion Criteria
- participants must be clearly competent to provide informed consent for research participation;
- participants must meet Diagnostic and Statistical Manual-5 diagnostic criteria for a principal diagnosis of a major depressive disorder or posttraumatic stress disorder
- participant must be a Veteran enrolled at Veterans Affairs Medical center within the Charleston VAMC catchment area
Exclusion Criteria
- recent history (< 2 months) of psychiatric hospitalization or a suicide attempt as documented in their medical record or reported during clinical interview
- current diagnosis of substance use disorder as documented in their medical record or reported during clinical interview
- acute, severe illness or medical condition that likely will require hospitalization and/or otherwise interfere with study procedures as documented in their medical record (e.g., active chemotherapy/radiation treatment for cancer, kidney dialysis, oxygen therapy for chronic obstructive pulmonary disease),
- recent start of new psychiatric medication (< 4 weeks)
- diagnosis of traumatic brain injury in their medical record and/or endorsement of screener questionnaire regarding the symptoms of traumatic brain injury modified from the Post-Deployment Health Assessment employed by the Department of Defense
- diagnosis of schizophrenia, psychotic symptoms, personality disorder, and/or bipolar disorder as documented in their medical record or reported during clinical interview
- VAMC patients excluded due to these factors will be reconsidered for participation once the condition related to their exclusion is resolved or stabilized
- Ineligible VAMC patients will be referred for non-study-related treatments within mental health at the Ralph H. Johnson VA Medical Center
Data sourced from ClinicalTrials.gov (NCT03979040). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.