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N/A N=68 Randomized Triple-blind Basic Science

Effect of rTMS on Anxiety

Anxiety · Fear · Anxiety and Fear

Bottom Line

View on ClinicalTrials.gov: NCT03993509 ↗
Enrolled (actual)
68
Serious AEs
0.0%
Results posted
Jan 2025
Primary outcome: Primary: Anxiety Potentiated Startle — 4.600026484; 3.411297242; 3.122643391; 4.848463905 T-scores

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
rTMS to the right dlPFC (Device)
Age
Adult · 18+ yrs
Sex
All
Sponsor
University of Pennsylvania
Primary completion
Nov 2022

Outcome Measures

OutcomeResultp-value
PRIMARY
Anxiety Potentiated Startle		 4.600026484; 3.411297242; 3.122643391; 4.848463905; 2.098026426; 1.347655375 —
PRIMARY
Fear Potentiated Startle		 7.598819444; 6.719283178; 6.564791401; 5.529855023; 5.61775824; 3.016188249 —
PRIMARY
Sternberg WM Accuracy		 80.70887446; 86.99776786; 84.89010989; 87.45039683; 81.38888889; 87.85342262 —
PRIMARY
TMS-evoked BOLD Responses		 -0.0074; -0.0063 —

Summary

Given the overall lack of treatment adherence/efficacy, side effects of drugs, and the substantial burden of anxiety disorders on the individual and on the national healthcare system, there is a critical need for mechanistic research into the CNS mechanisms that underlie these disorders. Accordingly, the objective of this grant is to use noninvasive neuromodulation to causally identify the key neural mechanisms that mediate the cognitive symptoms of anxiety. This project is relevant to public health because it has the potential to lead to novel repetitive transcranial magnetic stimulation treatments for pathological anxiety.

Eligibility Criteria

Inclusion Criteria

  • Subjects must be 18-50 years old
  • Able to give their consent
  • Right-handed

Exclusion Criteria

  • Non-english speaking
  • Any significant medical or neurological problems
  • Current or past Axis I psychiatric disorder(s), active or history of active suicidal ideation
  • Alcohol/drug problems in the past year or lifetime alcohol or drug dependence
  • Medications that act on the central nervous system
  • History of seizure
  • History of epilepsy
  • Increased risk of seizure for any reason
  • Pregnancy, or positive pregnancy test
  • IQ <80
  • Any medical condition that increases risk for fMRI or TMS
  • Any metal in their body which would make having an MRI scan unsafe
  • Any sort of medical implants
  • Hearing loss
  • Claustrophobia
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03993509). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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