N/A N=15 Treatment

Effects of Passive Heat Therapy on Oxygen Consumption and Cardiovascular Fitness in Adults

Heart Failure · Heart Diseases · Cardiovascular Diseases · Endothelial Dysfunction

Bottom Line

View on ClinicalTrials.gov: NCT04026126 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Oct 2022

Primary outcome: Primary: Change in Blood Pressure — -2.94; 0.85 mmHg

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Heat Therapy Treatment (Behavioral)
Age: Adult, Older Adult · 50+ yrs
Sex: All
Sponsor: University of Kansas Medical Center
Primary completion: Jul 2021

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in Blood Pressure	-2.94; 0.85	—
PRIMARY Change in Stroke Volume	9.02	—
PRIMARY Change in Stroke Volume Variation	—	—
PRIMARY Change in Cardiac Index	-0.36	—
PRIMARY Change in Systemic Vascular Resistance	9.02	—
PRIMARY Change in Maximum Oxygen Consumption (VO2max)	-0.13	—
PRIMARY Change in Concentration of Heat Shock Proteins	—	—
PRIMARY Change in Concentration of Nitric Oxide	—	—
PRIMARY Change in Concentration of Pro/Anti-inflammatory Markers	—	—

Summary

The purpose of this study is to determine if enhanced endothelial arterial distensibility observed with heat therapy translates into improved cardiorespiratory fitness. The following aims are proposed: Aim 1: to determine if chronic heat therapy results in improvements in cardiovascular function. Aim 2: To examine potential mechanism(s) of action of heat therapy in cardiovascular function.

Eligibility Criteria

Exclusion Criteria

Current major cardiovascular disease (i.e.: recent myocardial infarction (heart attack), stroke, angina pectoris, high grade coronary vasculopathy or atherosclerosis, severe valvular disease, cardiac dysrhythmia that requires treatment.
Current treatment with steroids or immunosuppressive agents
Cancer
Serious liver disease
End-stage renal disease
Judgement by medical provider that heat therapy poses an undue burden or risk
Women who are pregnant or plan to become pregnant

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04026126). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.