N/A
N=19
Effects of Transcranial Direct Current Stimulation (tDCS) on Language
Stroke · Aphasia
Bottom Line
View on ClinicalTrials.gov: NCT04166513 ↗Enrolled (actual)
19
Serious AEs
0.0%
Results posted
Mar 2025
Primary outcome: Primary: Percent Correct on Picture Naming and Reading Tasks (Baseline on Items Was 0) — 49; 72; 56; 56 percentage of items correct
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Targeted Transcranial Direct Current Stimulation (Device); Active Control Transcranial Direct Current Stimulation (Device); Phonologic-Focused Speech Therapy (Behavioral); Semantic-Focused Speech Therapy (Behavioral)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Medical College of Wisconsin
- Primary completion
- Jul 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Percent Correct on Picture Naming and Reading Tasks (Baseline on Items Was 0) |
49; 72; 56; 56; 47; 65 | — |
| SECONDARY fMRI- Baseline |
5; 5; 4; 5 | — |
| SECONDARY fMRI After Cycle A |
5; 4; 4; 4 | — |
| SECONDARY fMRI Post Cycle B |
4; 3; 3; 4 | — |
Summary
This study will investigate the effects of mild electrical stimulation in conjunction with speech therapy for people with post-stroke aphasia to enhance language recovery.
Eligibility Criteria
Inclusion Criteria
- Patients with a language deficit from focal neurologic damage (e.g. stroke, tumor).
- Patients must be adults and have English-language fluency.
- Patients must be eligible to undergo MRI.
Exclusion Criteria
- Advanced neurodegenerative disease (i.e. Stage 3 Alzheimer's disease) or neurologic disorder (e.g. idiopathic epilepsy, Parkinson's disease, ALS)
- Severe psychopathology (e.g. schizophrenia, bipolar disorder, acute major depressive episode)
- No suspected or diagnosed uncorrectable hearing or vision difficulties, or developmental disabilities (i.e. intellectual disability or learning disability).
- Contraindications to MRI such as claustrophobia, implanted electronic devices, MRI-incompatible metal in the body, extreme obesity, pregnancy, inability to lie flat, and inability to see or hear stimulus materials
Data sourced from ClinicalTrials.gov (NCT04166513). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.