N/A N=50 Randomized Double-blind Basic Science

Wayfinding Intervention in High-Fidelity Long-Term Memory

Long-Term Memory Decline · Mild Cognitive Impairment

Bottom Line

View on ClinicalTrials.gov: NCT04253587 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Feb 2023

Primary outcome: Primary: MDT Change in Mnemonic Discrimination — 0.09; 0.01 LDI score on a scale — p== 0.016

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: LabyrinthVR (Device); Placebo Games (Device); Coherence (Device); Tablet (Device)
Age: Adult, Older Adult · 62+ yrs
Sex: All
Sponsor: University of California, San Francisco
Primary completion: Dec 2021

Outcome Measures

Outcome	Result	p-value
PRIMARY MDT Change in Mnemonic Discrimination	0.09; 0.01	= 0.016 sig
PRIMARY WALK Change in Recall	0.03; 0.00	= 0.22
PRIMARY Changes in Volumetric-based Brain Morphometry Associated With Training-induced Changes in Mnemonic Discrimination	—	—
PRIMARY Changes in Task-based Cortical Functional Connectivity Associated With Training-induced Changes in Mnemonic Discrimination	—	—
SECONDARY Remote Cognitive Module (RCM)	—	—
SECONDARY Test of Visual Attention Change in Top-down Control	—	—

Summary

Therapeutic treatment is yet available for declining memory, which is an impairment affecting the quality of life for many older adults and patients with cognitive impairment. Cognitive training with an immersive video game promises to drive hippocampal-cortical plasticity and associated gains that can restore memory capability or provide therapeutic treatment for memory deficits.

Eligibility Criteria

Inclusion Criteria

fluent speakers of English
completed 12 or more years of education
normal or corrected-to-normal vision
dexterity to comfortably operate the scanner-compatible response box
freedom from physical and neurological conditions contra-indicated for fMRI
must confirm physical stamina and comfort for 45-minute, brisk walks on level ground

Exclusion Criteria

use of psychotropic medications
history of concussions or dizziness, vestibular or balance problems
significant discomfort with virtual reality experiences

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04253587). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.