N/A
Completed N=50
Wayfinding Intervention in High-Fidelity Long-Term Memory
Long-Term Memory Decline · Mild Cognitive Impairment
Source: ClinicalTrials.gov NCT04253587 ↗
Enrolled (actual)
50
Serious AEs
0.0%
Results posted
Feb 2023
Primary outcomePrimary: MDT Change in Mnemonic Discrimination — 0.09; 0.01 LDI score on a scale — p== 0.016
Summary
Therapeutic treatment is yet available for declining memory, which is an impairment affecting the quality of life for many older adults and patients with cognitive impairment. Cognitive training with an immersive video game promises to drive hippocampal-cortical plasticity and associated gains that can restore memory capability or provide therapeutic treatment for memory deficits.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY MDT Change in Mnemonic Discrimination |
0.09; 0.01 | = 0.016 sig |
| PRIMARY WALK Change in Recall |
0.03; 0.00 | = 0.22 |
| PRIMARY Changes in Volumetric-based Brain Morphometry Associated With Training-induced Changes in Mnemonic Discrimination |
— | — |
| PRIMARY Changes in Task-based Cortical Functional Connectivity Associated With Training-induced Changes in Mnemonic Discrimination |
— | — |
| SECONDARY Remote Cognitive Module (RCM) |
— | — |
| SECONDARY Test of Visual Attention Change in Top-down Control |
— | — |
Eligibility Criteria
Inclusion Criteria
- fluent speakers of English
- completed 12 or more years of education
- normal or corrected-to-normal vision
- dexterity to comfortably operate the scanner-compatible response box
- freedom from physical and neurological conditions contra-indicated for fMRI
- must confirm physical stamina and comfort for 45-minute, brisk walks on level ground
Exclusion Criteria
- use of psychotropic medications
- history of concussions or dizziness, vestibular or balance problems
- significant discomfort with virtual reality experiences
Data sourced from ClinicalTrials.gov (NCT04253587). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.