Phase 2 N=113 Nutraceutical Effects on Long-Term Memory
Aging
Primary: Delay Eyeblink Conditioning — 52.32; 56.88 percentage of conditioned responses
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=40 Preventing Cognitive Decline
Cognitive Decline
Primary: Percentage of Trials Correct On Working Memory Test — 87.69; 91.57; 88.01; 91.68 percentage of correct trials — p=>0.05
N/A N=30 Happy Older Latinos Are Active - Cognitive Decline
Cognitive Decline
Primary: Percentage of Participants Completing the Study — 90 Percentage of participants
N/A N=50 Wayfinding Intervention in High-Fidelity Long-Term Memory
Long-Term Memory Decline · Mild Cognitive Impairment
Primary: MDT Change in Mnemonic Discrimination — 0.09; 0.01 LDI score on a scale — p== 0.016
N/A N=184 Using TMS to Increase Executive Function in Older Adults
Aging
Primary: Acute Effect of a rTMS Session on the Performance for a Working Memory Task, as Measured by Accuracy (in Percentage) — 50.43; 55.42; 83.93; 46.49 percentage of accuracy
N/A N=122 Exercise Effects on Brain Health and Learning From Minutes to Months
Sedentary Lifestyle
Primary: Change in Hippocampal-dependent Learning — -.00369; .00404 learning rate (proportion correct/trial) — p=<.05
N/A N=22 Brain and Cognitive Changes After Reasoning Training in Individuals With Mild Cognitive Impairment
Mild Cognitive Impairment
Primary: Change From Baseline in California Verbal Learning Task Score — 3.04; 5.17; 4.22; 7.04 score on a scale
N/A N=38 Age-related Hearing Loss and Lexical Disorders
Alzheimer Disease · Presbycusis · Lexical Syntactic Disorder
Primary: Link Between Lack of Word and Presbycusis — 38; 38.5; 23; 21.5 score on a scale
N/A N=108 Better Memory With Literacy Acquisition Later in Life
Memory Impairment
Primary: Episodic Memory Improvement — 31.8; 31.3 score on a scale — p=0.531
N/A N=78 Semantic Memory, Financial Capacity, and Brain Perfusion in Mild Cognitive Impairment (MCI) (CASL)
Alzheimer Disease · Dementia
Primary: FCI Score at Follow-up — 147.3; 164.0; 123.3; 150.8 points awarded for correct items
N/A N=59 Mnemonic Strategy Versus Spaced Retrieval Training in Those With Mild Cognitive Impairment
Mild Cognitive Impairment
Primary: Percent of Correct Object Location Associations Assessed up to 1 Month Post-treatment — 80.0; 62.45 percent correct — p=<.001
N/A N=38 tDCS and Cognitive Efficiency in Ageing
Aging · Mild Cognitive Impairment · Alzheimer Disease
Primary: Complutense Verbal Learning Test (TAVEC) - Memory — 0.94; -0.81; 1.65; -0.31 units on a scale
N/A N=81 Memory and Fear Study (Fear of Memory Loss Study)
Anxiety and Fear
Primary: Fear and Avoidance of Memory Loss (FAM) Scale Score at Follow-up — 63.9; 60.3 score on a scale
Phase 2 N=125 Cognitive Decline and Alzheimer's Disease in the Dallas Lifespan Brain Study
Alzheimer Disease · Cognitive Decline
Primary: Standardized Uptake Value Ratios (SUVrs) Calculated From [18F]AV-1451 PET Scans — 1.09 standardized uptake value ratio
Phase 4 N=121 Emotional and Cognitive Control in Late-Onset Depression
Depression
Primary: Change in Depression Severity (Measured by Montgomery Asberg Depression Rating Scale) — 25.26; 1.03; 13.78; 1.08 score on a scale — p=< 0.025
N/A N=107 Cognitive Training and Neuroplasticity in Mild Cognitive Impairment
Mild Cognitive Impairment · Memory Disorders · Memory Impairment
Primary: Change in the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) — -0.89; 0.55 score
N/A N=112 Semantic Learning Deficits in School Age Children With Developmental Language Disorder
Developmental Language Disorder
Primary: Mean Percent Correct Semantic Meaning Identification — 73.6; 75.12; 77.1; 82.3 percentage of correct responses — p=0.36
Phase 4 N=47 A Study of L-DOPA for Depression and Slowing in Older Adults
Major Depressive Disorder · Dysthymia · Depression Not Otherwise Specified
Primary: Hamilton Rating Scale for Depression (24 Item) — 10.94 Units on a Scale
Phase 2 N=30 The Efficient Brain Study
Metabolism - Cerebral Energy
Primary: Magnetic Resonance Spectroscopy (MRS) Will Measure a Change in Cerebral Energy Function in Brain Tissue — .011; .007; .009; .006 Difference in metabolite amplitude
Phase 4 N=100 Remediation of Age-related Cognitive Decline: Vortioxetine and Cognitive Training
Age-related Cognitive Decline
Primary: Change in Total Fluid Cognitive Score — 6.14; 3.71; 106.06; 105.85 score on a scale
N/A N=107 Promoting Adaptive Neuroplasticity in Mild Cognitive Impairment
Mild Cognitive Impairment · Alzheimer's Disease
Primary: Face-name Memory Test Performance — -.28; -.01; -1.29; -1.76 pairs correctly recalled/recognized
N/A N=28 Exercise Effects on Word Learning
Aging · Aphasia
Primary: Study-Specific Word Recall Task — 6.4; 1.7; 4.6; 1.5 number of words gained
N/A N=28 Retrieval-Based Word Learning in Developmental Language Disorder
Developmental Language Disorder · Specific Language Impairment · Language Development
Primary: Word Form Recall Accuracy (Number of Words Correctly Recalled) on Expanding and Standard Retrieval Schedules at 5 Mins — 3.93; 6.43; 3.71; 5.21 number of words recalled…
Phase 3 N=1,537 Effect of LY450139 on the Long Term Progression of Alzheimer's Disease
Alzheimer's Disease
Primary: Change From Baseline in Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog11) Score at 76 Weeks — 6.19; 7.29; 7.68 units on a scale — p=0.134
N/A N=90 The Effects of Mixed Working Memory Training on Subsequent Training Gains Among Older Adults
Cognitive Aging
Primary: Change in Overall Working Memory — 0.42; 0.26; -0.01; 0.04 Standard unit change — p=0.355
N/A N=33 Memory Consolidation in Obstructive Sleep Apnea
Obstructive Sleep Apnea
Primary: Overnight Change in Declarative Memory Performance — 11.2; 6.5 percent change in performance
N/A N=253 Lifestyle Physical Activity and Cognitive Training Interventions
Cognitive Decline · Cardiovascular Diseases · Cognitive Dysfunction
Primary: Change in East Boston Memory Test Scores From Baseline to 24 Weeks, 48 Weeks, and 72 Weeks — 0.03; -0.02; 0.01; 0.05 score on a scale — p=.409
Phase 4 N=83 Lithium As a Treatment to Prevent Impairment of Cognition in Elders
Mild Cognitive Impairment
Primary: California Verbal Learning Test II — 6.9; 6.2; 6.46; 5.10 units on a scale — p=0.048
Phase 2 N=80 Metformin in Amnestic Mild Cognitive Impairment
Mild Cognitive Impairment
Primary: Change in Total Recall Score in the Selective Reminding Test — 5.7; 9.4 score on a scale — p=0.05
N/A N=68 Everyday Memory Intervention
Aging
Primary: Everyday Memory Failures — 0.55; 0.62 average daily number memory failures/day — p=.67