Anti-Androgen Treatment for COVID-19

Inclusion Criteria

• Male age ≥18 years old
• Laboratory confirmed positive SARS-CoV-2 rtPCR test within 7 days prior to randomization
• Clinical status on the COVID-19 8-point Ordinal Scale of 1 or 2
• Coagulation: INR ≤ 1.5×ULN, and APTT ≤ 1.5×ULN
• Subject (or legally authorized representative) gives written informed consent prior to any study screening procedures
• Subject (or legally authorized representative) agree that subject will not participate in another COVID-19 trial while participating in this study

Exclusion Criteria

• Subject enrolled in a study to investigate a treatment for COVID-19
• Subject taking an anti-androgen of any type including: androgen depravation therapy, 5-alpha reductase inhibitors, etc…
• Patients who are allergic to the investigational product or similar drugs (or any excipients);
• Subjects who have malignant tumors in the past 5 years, with the exception of completed resected basal cell and squamous cell skin cancer and completely resected carcinoma in situ of any type
• Subjects with known serious cardiovascular diseases, congenital long QT syndrome, torsade de pointes, myocardial infarction in the past 6 months, or arterial thrombosis, or unstable angina pectoris, or congestive heart failure which is classified as New York Heart Association (NYHA) class 3 or higher, or left ventricular ejection fraction (LVEF) 450 ms
• Subjects with uncontrolled medical conditions that could compromise participation in the study(e.g. uncontrolled hypertension, hypothyroidism, diabetes mellitus)
• Known diagnosis of human immunodeficiency virus(HIV) , hepatitis C, active hepatitis B, treponema pallidum (testing is not mandatory）
• Alanine Transaminase (ALT) or Aspartate Transaminase (AST) > 5 times the upper limit of normal.
• Estimated glomerular filtration rate (eGFR) < 30 ml/min
• Severe kidney disease requiring dialysis
• Subject unlikely to return for day 15 site visit for reasons other then remission
• Subject (or legally authorized representative) not willing or unable to provide informed consent