N/A N=108 Double-blind Prevention

Better Memory With Literacy Acquisition Later in Life

Memory Impairment

Bottom Line

View on ClinicalTrials.gov: NCT04473235 ↗

Enrolled (actual)

108

Serious AEs

0.0%

Results posted

Jul 2024

Primary outcome: Primary: Episodic Memory Improvement — 31.8; 31.3 score on a scale — p=0.531

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Literacy training (Behavioral); Non-Literacy training (Behavioral)
Age: Adult, Older Adult · 40+ yrs
Sex: All
Sponsor: University of California, San Francisco
Primary completion: Dec 2022

Outcome Measures

Outcome	Result	p-value
PRIMARY Episodic Memory Improvement	31.8; 31.3	0.531
SECONDARY Change in Brain Connectivity	-0.11; 0.06; -0.11; -0.05	0.627

Summary

This study aims to discover whether acquiring basic-literacy in adulthood can improve episodic memory and brain structural and functional connectivity. In a collaborative project between Brazil and USA, the investigators will use a randomized controlled trial approach to leverage the level of evidence of the benefits of basic adult-education as a possible cognitive reserve builder. If successful, the study's findings will be important in shaping policies targeting increasing access to late-life education to reduce dementia risk.

Eligibility Criteria

Inclusion Criteria

Being illiterate (TOFHLA score <53) and availability to participate in the study for at least 12 months

Exclusion Criteria

A) Presence of remarkable cognitive complains and/or decompensated psychiatric illness (depression and anxiety) and/or current substance abuse such as alcohol and illicit drugs use.

B) Objective cognitive impairment: score of 2 standard deviations or bellow for age and education on the Mini-Mental State Evaluation (MMSE) and/or score of 6 or lower on the delayed recall task from the Brief Cognitive Battery.

C) History of previously diagnosed dyslexia D) Formal MRI contraindications including metal or claustrophobia. E) Severe structural lesions detected by MRI.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04473235). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.