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Memory impairment

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for memory impairment

13 trials tracked for memory impairment: 5 in phase 3 or 4 and 2 with published results. The most-cited published study has 71 citations.

13Trials tracked

5Phase 3 & 4

0Recruiting

2With published results

Phase distribution

Phase 4 3 Phase 3 2 Phase 2 2 Phase 1 1 Other / NA 5

Phase 3 The Healthy Patterns Sleep Study Completed · 71 cited
Phase 3 Phase 3 Randomized Placebo Controlled Clinical Trial of Donepezil Completed · 21 cited
Phase 4 Reversing Corticosteroid Induced Memory Impairment Completed
Phase 4 Study to Assess the Efficacy of Cognitex Completed
Phase 4 The Efficacy of Phosphatidylserine-Omega3 in Elderly Subjects With Memory Impairment Completed
Phase 2 Vilazodone for Corticosteroid-Induced Memory Impairment Completed

Show 7 more trials

Phase 2 Effect of Insulin Sensitizer Metformin on AD Biomarkers Completed
Phase 1 Roflumilast and Donepezil to Reverse Scopolamine Induced Cognitive Deficits in Healthy Adults Completed
N/A Exercise in Adults With Mild Memory Problems Completed
N/A Our Care Wishes - Dementia Completed
N/A Cognitive Training and Neuroplasticity in Mild Cognitive Impairment Completed
N/A Noninvasive Brain Stimulation for Mild Cognitive Impairment Completed
N/A Better Memory With Literacy Acquisition Later in Life Completed

Showing the 13 most-cited and recently-updated of 13 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Memory impairment: what the trials found

Several interventions have been evaluated for memory impairment, including Lamotrigine ¹, Phosphatidylserine-Omega3 (SharpPS-Gold) ², and Cognitex ³. Additionally, an attention-control condition was studied in a larger cohort ⁴.

Clinical trials evaluating pharmacological options showed mixed results. Specifically, Donepezil 5 mg did not produce a statistically significant change in the Hopkins Verbal Learning Test-Revised (HVLT-R) total scores (p=0.32) ⁵.

Recent results — preliminary, needs further review

Active rTMS (Bilateral DLPFC) showed no statistically significant improvements in word recall, list learning, or CVLT-II semantic clustering at 1 week (p=0.63; p=0.29) or 3 months (p=0.45) post-intervention ⁹.

For the clinician treating this condition

Evidence for the efficacy of Donepezil 5 mg in improving HVLT-R scores is not statistically significant ⁵.
Current evidence for active rTMS (Bilateral DLPFC) does not demonstrate significant improvements in memory metrics at either 1 week or 3 months post-intervention ⁹.

AI synthesis of 6 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.