N/A Completed N=154 Randomized Double-blind Treatment

Mindfulness Oriented Recovery Enhancement for Chronic Pain and Opioid Relapse

Opioid Use Disorder · Postoperative Pain

Source: ClinicalTrials.gov NCT04491968 ↗

Enrolled (actual)

154

Serious AEs

0.0%

Results posted

Mar 2025

Primary outcomePrimary: Drug Relapse Through 16-weeks. — 39; 44 Participants — p=.02

Summary

The objective of this study is to rigorously examine the impact of online MORE, delivered through video conference, on opioid use and chronic pain among individuals receiving methadone maintenance treatment (MMT). This study is a randomized controlled trial to test the efficacy of online MORE on opioid use and chronic pain immediately after treatment and 8-weeks post-treatment as compared to treatment as usual (TAU) among 154 individuals in MMT. Further, mediators (i.e., metacognitive awareness, negative emotion regulation, and natural reward processing) and moderators (i.e., gender, race, income, mental health, trauma, and MMT phase) of treatment response will be explored.

Outcome Measures

Outcome	Result	p-value
PRIMARY Drug Relapse Through 16-weeks.	39; 44	.02 sig
PRIMARY Methadone Treatment Drop Out Through 16-weeks.	10; 17	.04 sig
SECONDARY Number of Days of Any Drug Use	13.9; 21.7	—
SECONDARY Number of Days of Opioid Use.	7.9; 8.5	—
SECONDARY Number of Days of Other Drug Use.	9.8; 18.3	—
SECONDARY Changes in Craving	-.49; -.35	—
SECONDARY Changes in Pain.	-.62; -.25	—
SECONDARY Changes in Depression.	-3.68; -2.36	—
SECONDARY Changes in Anxiety.	-2.51; 1.31	—

Eligibility Criteria

Inclusion Criteria

English-speaking
Age ≥18
Currently on methadone
Experiencing non-malignant pain for a duration of 3 months or longer.

Exclusion Criteria

Severe cognitive impairment or active psychosis
Suicide risk
Inability to attend the MORE group, if randomized to that arm.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04491968). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.