N/A N=26 Randomized Double-blind Treatment

Noninvasive Brain Stimulation on Memory in Individuals With Mild Cognitive Impairment and History of Brain Injury

Amnestic Mild Cognitive Impairment · Traumatic Brain Injury · Mild Traumatic Brain Injury

Bottom Line

View on ClinicalTrials.gov: NCT04504630 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

May 2025

Primary outcome: Primary: Hopkins Verbal Learning Test-Revised Total Learning — 35.8; 35.9; 34.2; 31.6 T-score on a scale

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: High Definition Transcranial Direct Current Stimulation (Device); Sham HD-tDCS (Device)
Age: Adult, Older Adult · 50+ yrs
Sex: All
Sponsor: University of Texas Southwestern Medical Center
Primary completion: Jun 2024

Outcome Measures

Outcome	Result	p-value
PRIMARY Hopkins Verbal Learning Test-Revised Total Learning	35.8; 35.9; 34.2; 31.6; 32.7; 37.1	—
PRIMARY Hopkins Verbal Learning Test-Revised Delayed Recall	30.1; 31.0; 27.7; 26.9; 26.9; 32.4	—
PRIMARY Brief Visuospatial Memory Test-Revised (BVMT-R) Total Learning	33.0; 29.1; 32.3; 33.3; 33.8; 34.1	—
PRIMARY Brief Visuospatial Memory Test-Revised Delayed Recall	32.6; 32.4; 32.4; 32.0; 31.6; 32.4	—
SECONDARY Phonemic Fluency	45.8; 49.1; 46.3; 53.0; 49.1; 54.6	—
SECONDARY Semantic Fluency	38.4; 37.4; 38.6; 42.2; 37.3; 38.4	—
SECONDARY Trail Making Test	41.6; 41.9; 45.7; 44.1; 47.8; 39.1	—
SECONDARY Stroop Color and Word Test	38.8; 39.1; 41.6; 40.0; 39.9; 37.9	—
SECONDARY Digit Span Test	10.8; 9.8; 10.6; 10.4; 10.8; 9.4	—

Summary

The study will examine the efficacy of high definition transcranial direct current stimulation (HD-tDCS) and its influence on episodic memory in patients with amnestic mild cognitive impairment and a history of Traumatic brain injury. Ten sessions of HD-tDCS to the dorsal anterior cingulate region is expected to result in improvements in episodic memory measures immediately following the last session and at a 3-month follow-up.

Eligibility Criteria

Inclusion Criteria

Age 50 and older
Native English speakers
12 years of education or higher
Active diagnosis of aMCI
History of TBI based on VA/DOD criteria

Exclusion Criteria

TBI within the past 2 years
Lifetime history of stroke, transient ischemic attack, heart attack, or congestive heart failure
Lifetime history of epilepsy
Major psychiatric disorders (i.e., posttraumatic stress disorder, bipolar disorder, schizophrenia)
Substance use disorder
Has metal fragments in head
Taking medications that may interact with the HD-tDCS effect (i.e., amphetamines, L-dopa, carbamazepine, sulpiride, pergolide, lorazepam, dextromethorphan, D-cycloserine, flunarizine, or ropinirole)

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04504630). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.