Clinical Trial Search

Primary: Change in Total Recall Score in the Selective Reminding Test — 5.7; 9.4 score on a scale — p=0.05

Primary: FCI Score at Follow-up — 147.3; 164.0; 123.3; 150.8 points awarded for correct items

Primary: Face-name Memory Test Performance — -.28; -.01; -1.29; -1.76 pairs correctly recalled/recognized

Primary: Annualized Percent Change in Ventricular Volume (APCV) as Measured by MRI — 5.87; 8.14; 6.26; 7.08 percent change per participant year

Primary: Change in Clinical Dementia Rating Scale - Sum of Boxes (CDR-SB) Score From Baseline — 1.1; .9 score on a scale

Primary: Rey Auditory Verbal Learning Test (Total Delayed Recall) — 6.43; 7.83 score on a scale — p=0.11

Primary: Brain Activity in the Dentate Gyrus / CA3 Subregion of the Hippocampus Measured With Blood Oxygenation Level Dependent (BOLD) Functional MRI — -0.1203; 0.4353; -0.2238…

Primary: Hopkins Verbal Learning Test-Revised (HVLT-R) — 23.52; 20.04; 23.68; 20.39 score on a scale

Primary: Change in the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) — -0.89; 0.55 score

Primary: Change in Cognitive Performance — 0.8; 0.7; 1.2; 0.4 units on a scale — p=<0.0125

Primary: N-acetylaspartate — 1.35; 1.86; 1.58; 1.26 NAA/creatine Ratio

Primary: Selective Reminding Test (SRT) — 33.61; 36.23; 36.81; 37.13 Words

Primary: Change in Standardized Uptake Value Ratio (SUVR) of (18F-Florbetapir PET) From Week 0 to Week 52. — 0.07; 0.08 Standardized Uptake Value Ratio

Primary: Auditory Memory Attention Index — 89.0; 94.3 standard score units — p=<0.01

Primary: Change in Alzheimer's Disease Assessment Scale-cognitive Subscale (ADAS-cog) — 2.83 score on a scale — p=0.002

Primary: Change in Readiness to Engage in ACP (ACP Engagement Scale) — 1.92; 1.54; 2.77; 2.00 units on a scale

Primary: Alzheimer's Disease Cooperative Study- Clinical Global Impression Change (ADCS-CGIC) — 3.92; 3.48 scores on the CGIC

Primary: Percent of Correct Object Location Associations Assessed up to 1 Month Post-treatment — 80.0; 62.45 percent correct — p=<.001

Primary: Percent Change From Baseline to Week 12 Based on Hippocampus Connectivity Index (HCI) — 7.47 percent change

Primary: Change in Score on the Rey Auditory Verbal Learning Test (RAVLT) — 13.8; 17.8; 18.0; 13.4 T-score on a scale — p=0.25

Primary: Change in Selective Reminding Test - Total Immediate Recall (SRT-IR) — 7.5 units on a scale

Primary: Divided Attention Performance — 9.29; 9.31 difficulty level acheived

Primary: Number of Participants With Treatment-Emergent Adverse Event (TEAEs) — 34; 26 Participants

Primary: Number of Participants With a Decline of 6 Points on the Hopkins Verbal Learning Test-Revised (HVLT-R) — 1; 9 Participants — p=.02

Primary: Retention and Recruitment Rates — 21 Participants

Primary: Changes in the Metabolite Ratios of N-acetylaspartate (NAA) to Creatine (Cr), Myo-inositol (mI) to Cr, Choline (Cho) to Cr, NAA to Cho, and NAA to mI, on Cholinesterase…

Primary: Total Number of Words Correctly Recalled, List Learning, California Verbal Learning Test-II, Assessed 1 Week After Intervention and Adjusted for Baseline Performance…

Primary: Feasibility of a Virtual Multicrossover Randomized Control Trial Design as Measured my Completion Rates and Medication Compliance. — 7; 7; 7 Participants

Primary: Functionality in Activities of Daily Living (Changes in Scores Approach) — 0.1; 0; -0.1; -0.2 units on a scale — p=.145

Primary: Amyloid Deposition Obtained on a 18F-flutemetamol Brain Scan. — 1.65 ratio of flutemetamol absorbed — p=<0.05